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Phase 2a Setipiprant Male Hair Loss Treatment Trials Recruiting

A US-headquartered pharmaceutical giant which has started to investigate new treatment options in the field of hair loss is looking for people to take part in a clinical trial.

Allergan is seeking men with the genetic condition Male Pattern Baldness for a trial that will take place at multiple centres across the USA and may offer hope to men whose thinning hair is located and visible along the top of their head.

The trial has been ongoing since last summer, but Allergan have recently extended the age range for potential participants from 18-41 to 18-49.

Vertex Hair Growth Study

Clinical trials are abundant and typically go by a rather dry-sounding name that explains their purpose, but when they receive backing from a major corporation they are sometimes given titles that are somewhat grander. Allergan’s trial is no exception, and the company has named its Phase 2a study of setipiprant tablets on men with Androgenetic Alopecia as the “Vertex Hair Growth Study”.

Vertex, in this case, means “the top of the head”, and it may be inferred from the trial details that the researchers behind it do not, perhaps, see much promise in the drug at restoring a thinning hairline. In men with Male Pattern Baldness, the two places most commonly affected are the crown/vertex and also the hairline, which is why Male Hair Loss treatment typically involves the use of two separate products to tackle the shedding.

The current market-leading product that is licensed by the MHRA in the UK and the FDA in the US to tackle vertex thinning is finasteride 1mg. It would appear that Allergan’s setipiprant is being developed to go up against this.

One immediate drawback – at least based on current information – is that the setipiprant being administered in the Allergan trial appears to be a drug that is taken twice daily, as opposed to the once-daily finasteride. This automatically puts it at something of a disadvantage, because remembering to take pills is a common issue with any medical regime.

It could be that Allergan is hoping that their product outperforms the already effective finasteride 1mg, or perhaps they are hoping for a more affordable price-point. They will have a clearer idea of the efficacy of their drug by March 2018, by which time the study is due to be completed. Just over 150 people are expected to take part.

mens-hair-loss-treatmentTwo-pronged attack on hair loss?

What may be driving Allergan’s hair loss ambitions – and this is merely speculation – is that they are planning a two-pronged attack on Androgenetic Alopecia, including an attempt to reverse thinning around the hairline, to take on the current go-to treatment combination of finasteride 1mg and minoxidil.

Minoxidil is a liquid which can be applied where it is needed; what may be the company’s long-term goal is to offer an alternative option for men with hair loss that involves setipiprant alongside another drug they are trialling which is based around bimatoprost, an ingredient in several glaucoma drugs and which just happens to be a liquid – like minoxidil.

What is certainly true is that demand for clinically-proven hair loss treatment is extremely high, as around half of all men will be affected by it by the time they are 50. While not all of them will seek out remedies to try and combat a thinning crown or to regrow a receding hairline, those many thousands around the world that do ensure there will always be pharmaceutical companies keen to bring new hair loss solutions to the market designed to prevent baldness.

The Belgravia Centre Hair Loss Clinic - Hair Loss Specialist ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.

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27th July, 2017 at 3:56 pm


Is it possible for Belgravia to register as one of the centres participating in the trial. I know that this is an FDA trial and therefore there are issues conducting it outside the USA but if the participants were willing to sign a disclaimer, would it be theoretically possible? Looking at the page on clinicaltrials.gov they dont seem to be overwhelmed with paricipants

27th July, 2017 at 5:11 pm

Sarah Belgravia

Hi Andrew. We generally do not get involved with clinical trials in the US or the UK, not least because it would take the staff in our busy London hair loss clinics away from Belgravia's primary concern, which is providing the highest standard of client care to our patients. The records at clinicaltrials.gov are not always up-to-the-minute correct so for a better picture of how the trial is coming along and if there is a way of taking part under the supervision of your GP, perhaps, we recommend you contact the researchers directly. Their details should be on the site record.

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