Powder Finasteride Microneedling Treatment for Male Hair Loss

There are currently only two clinically-proven, MHRA-licensed and FDA-approved hair loss medications authorised to treat the common, hereditary condition, Male Pattern Baldness.

Male Pattern Hair Loss Treatment and Hair Growth Supporting Products The Belgravia Centre Hairloss Clinic

One is the vasodilator high strength minoxidil, which is used to encourage accelerated hair growth, whilst the other is an oral tablet, finasteride 1mg, which can be taken by medically-suitable men aged 18 and over, to inhibit the formation of dihydrotestosterone - DHT.

This is the hormone which can start attacking the hair follicles in genetically-predisposed men any time following puberty, causing gradually thinning hair along the top of the scalp - the 'vertex' - from crown to temples - and a receding hairline. This can lead to eventual baldness in these affected areas if left unchecked.

Researchers have been trying to develop a topical form of finasteride 1mg, for a number of years, the reasoning being applying the drug directly to the scalp may have a reduced potential side effect profile, and it may also be able to be used by some women.

So far, this has tended to revolve around exploring the safety, tolerability and efficacy of experimental finasteride spray or gel solutions.

However, new research coming out of Seoul, in the Republic of Korea, has shown that transdermal delivery of finasteride powder using microneedles and a diffusion enhancer may also be a worthwhile candidate.

Sustained drug release over three day period

The team from the Department of Biotechnology at Yonsei University and Juvic Inc. developed a topical formulation of powder finasteride (FNS) and a novel delivery system involving transdermal microneedles coated with the powder, to create micro-channels in the skin for the drugs to pass through.

Whilst microneedling is popular among some topical hair loss treatment users, we are only aware of small-scale trials into its efficacy and safety having been carried out to date. The Korean research authors advise a "low delivery efficiency and concerns over patient safety of SMNs remain major limitations of the treatment."

Insulin Patch Could Help Diabetics to Prevent Hair Loss
An example of a transdermal microneedle patch which UNC School of Medicine is trying to develop to deliver insulin

It was for this reason the team invented a novel, patchless powder-finasteride delivery system which could be self-administered straight into the skin without the previous safety issues associated with solid microneedles - the type typically found on home-use microneedling devices such as dermarollers.

Transdermal microneedle patches have been used to deliver medication in a number of illnesses and health conditions already, and it is an area of medicine which is currently being explored for a range of potential uses, including insulin patches to help manage diabetes.

The South Korean team advised in their report, published in the Journal of Controlled Release, "we introduced the concept of a diffusion enhancer for this system, which facilitated the dissolution and release of the implanted FNS powder to achieve its successful intradermal delivery.

Using implanted FNS powder as a reservoir inside the skin, this novel system permitted sustained release of the implanted FNS powder for 3 days with only one application of FNS-PCMs .

In addition, compared with the topical FNS-gel, the developed system showed a higher efficacy in promoting hair growth and increased the amount and density of hair while addressing the safety concerns."

Belgravia superintendent pharmacist and senior hair loss specialist, Christina Chikaher, said of the news, "As long as the amount of powder released into the skin can be properly controlled, this could be a possible treatment for the future. The article says that this can be self-administered, though I couldn't find information on how they ensured accurate drug delivery, but it looks promising. I am always of the belief that a topical preparation of finasteride, well-delivered, could have beneficial results with a potentially reduced potential side effect profile." Continues below...

Journal of Controlled Release - November 2019 - Transdermal Powder Finasteride Microneedle Delivery Trial for Male Pattern Baldness - Diagrams
Diagrams from the Journal of Controlled Release Transdermal Powder Finasteride Microneedle Delivery Trial. Source: https://doi.org/10.1016/j.jconrel.2019.11.002

Current options for Male Pattern Hair Loss treatment

Whilst the potential risk of serious side effects from finasteride 1mg is currently considered 'uncommon', affecting an estimated one in every 100 users, some men looking at preventing baldness do opt for alternative treatments.

This approach generally revolves around the use of a customised male hair loss treatment course featuring formulations of the aforementioned, dose-dependent topical solution, high strength minoxidil, used once or twice per day, as advised by the recommending hair loss specialist.

This topical treatment can be supplemented with a number of hair growth supporting products, including the FDA-cleared LaserBand. This popular, wearable device features patented teeth which comb through the hair, parting it as it's worn, so the medical-grade low level laser therapy (LLLT) it dispenses gets straight to the scalp, rather than just the hair. This allows it to stimulate the follicles, encouraging strong, healthy hair.

HairMax, the device's manufacturers, claim the LaserBand products which are used 3 times per week for either 90 seconds (82 model) or 3 minutes (41 model) have a 93 per cent success rate.

Belgravia offers its clients additional elements such as clinical therapy sessions at its London hair loss clinics, whereby a personalised session featuring a relaxing mix of therapies such as scalp massage, red light therapy, LLLT and scalp steaming, to help boost hair health.

Hair Vitalics for Men, an exclusive one-a-day food supplement developed by Belgravia hair experts, also fits well with a pharmaceutical treatment plan, though it can also be taken to simply help maintain normal healthy hair growth. It contains a highly-targeted blend of vitamins, minerals, amino acids and botanicals, including biotin, zinc, selenium and saw palmetto.

If you are worried about losing your hair, either after noticing signs of hairloss or feeling a drop in your usual hair density, and would like to explore ways to keep your hair, although many of the treatments in development may sound fantastic, they could still be a long way off yet. Therefore, given Male Pattern Baldness is a permanent and progressive condition, it's wise to seek advice on what options may be best for you, as early on in the process as possible.

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The Belgravia Centre

The Belgravia Centre is a world-renowned group of a hair loss clinic in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation from anywhere in the world for home-use treatment.

View our Hair Loss Success Stories, which includes the world's largest gallery of hair growth photos and demonstrates the level of success that so many of Belgravia's patients achieve.

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