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A clinical trial involving a topical hair loss solution it was hoped may treat the autoimmune disorder Alopecia Areata has been terminated.

Minoxidil DropperThe reason stated for the LEO 124249 treatment trial cancellation is ‘futility’, according to the ClinicalTrials.gov database.

LEO 124249 topical alopecia solution

The issue as to whether a topical hair loss product that appeared to have similar properties to another topical treatment already available, was a point raised on the Belgravia blog when the LEO Pharma trial registration was announced in 2016.

Whilst this was not confirmed, the fact that the clinical trial has been suspended in the manner it has suggests that the treatment was considered futile for one of two reasons: either the solution itself did not work, or it was too similar to existing drugs to be worthwhile developing further. The latter point could be particularly pertinent if other solutions were more tolerable, safer with a lower side-effect profile, more effective or simply cheaper.

What this development certainly does not mean is that developing an effective treatment for Alopecia Areata is pointless. It is, in fact, an area of great interest and activity, especially when it comes to the forms not currently treatable – Alopecia Totalis and Alopecia Universalis – and for all types in children aged 15 and under.

Currently the only form which can be treated is the scalp-only phenotype, and then only in medically-suitable over 16s.

Alopecia treatments

At present the suite of drugs known as Janus Kinase inhibitors have seemingly produced the most successful results during clinical trials. Both topical and oral JAK inhibitor drugs are in late-stage testing to treat all forms of autoimmune alopecia, and the latest estimate for a potential release date – should these meet all necessary medical regulatory board criteria – is 2021.

A further drug based on a JAK inhibitor has also shown promise and has been fast-tracked for development by the FDA. This expedition was granted due to the unmet needs of Alopecia Totalis and Universalis patients.

Whilst the age group either treatment will cater to remains unconfirmed, reported clinical trial data has so far largely concentrated on adults aged 18 and above. A recent trial registration has confirmed that one JAK inhibitor – tofacitinib – is being explored as a potential children’s treatment for mild to severe Alopecia Areata.

In the meantime, hair loss charities and services such as paediatric psychodermatology, can help younger children – and their support networks – to cope with the emotional effects of these noticeable conditions.

For adults, if the hair loss is confined to the scalp, Belgravia offers a range of treatment options, but if baldness occurs in any other hair-bearing areas, from facial hair, eyebrows and eyelashes, to the entire body, it is wise to contact a doctor for further advice.


The Belgravia Centre Hair Loss Clinic - Hair Loss Specialist ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Later this Summer we will be saying ‘goodbye’ to the original Belgravia Centre flagship hair loss clinic in Victoria, and ‘hello’ to a new location in Pimlico.

Belgravia Centre Hair Loss Clinics - Central London City of LondonThe move from Grosvenor Gardens to our new Longmoore Street site will offer clients a modern experience in a bigger, yet more boutique, discreet setting just minutes from both Victoria and Pimlico stations.

Belgravia’s contemporary Central London hair loss clinic will, of course, still maintain the trademark warmth and professionalism our staff are known for.

This relocation will not affect Belgravia’s City of London clinic on New Street, opposite Liverpool Street Station, which is now in its 5th year and going from strength to strength.

We are working hard to ensure the transition is as smooth as possible for all existing Grosvenor Gardens clients, and further information – including opening hours – will be sent out to each patient nearer the time. However, as the new clinic is still very close to Victoria Station – just via a different exit – there should be minimal inconvenience and we’re sure everyone will enjoy the superior setting in leafy Longmoore Street.

For those visiting Belgravia from out of town, there are a range of hotels just a few minutes walk from the new hair clinic, ranging from the easyHotel Victoria, and the Best Western Victoria Palace, to the Park Plaza and DoubleTree by Hilton. The Apollo theatre is also a short stroll away, for anyone wanting to combine their consultation or check up with some Wicked-ness! It is also convenient for drivers, being just off Vauxhall Bridge Road and with various car parks and motorbike bays in the vicinity.

Check back for updates the move and to see the new clinic, as we will be posting details here on our hair loss blog. In the meantime, it’s business as usual at both clinics and you can still visit us for a consultation, check-up, clinical therapy session, or to collect hair loss treatment from our dedicated pharmacies.

For anyone who wishes to get a head start on updating their address books, the new Belgravia Centre’s address will be…

The Belgravia Centre
9 Longmoore Street
London SW1V 1JH

We look forward to showing you around!


Circ - Belgravia Centre Hair Loss Clinics LondonThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 20 06 2018A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr C, pictured, has seen improvement in the thinning areas since starting his personalised treatment course.

Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Name: Thomas

Question: The front of my hair is starting to thin and I’m only a 21 year old man , I use to relax my hair and now have stopped doing so. Is there anyway I can make the front of my hair less thin as I have to now keep cutting it short to make up for the thinning of my hair.

Answer: Hi, Thomas. We would need to assess your scalp in order to confirm any diagnosis but, from what you say here, there could be three or four potential issues causing your hair loss. Here is a brief rundown of each, but we would definitely recommend having a professional consultation, either in person or online using a photo upload tool.

Thinning Hair Loss After Relaxing Hair Mens hairstyles Afro Hair

1. Hair Breakage – this happens when the hair becomes weak enough to snap along the shaft. It is not a hair loss condition as it does not affect the follicle, however, it can make hair look thinner than normal. Generally the best way to deal with this is to have a good haircut to help keep the healthy hair, and use strengthening conditioning treatments to restore damaged hair. Ensuring a good supply of hair-friendly nutrients via your diet is also a good way to encourage healthy hair growth; topping up with dedicated supplements, such as Hair Vitalics for Men, is also a popular option.

2. Chemical Trauma – this normally occurs from either over-use of chemical hair products, such as relaxers or bleach, or using solutions which are too strong. The resulting hairloss is effectively a type of burn and can vary from temporary to permanent depending on the severity of the damage caused. As long as the hair follicles are still functioning, a custom chemical trauma hair loss treatment course may be followed. If the areas of hair loss are so badly affected that they become bald, this is a sign that the follicles are no longer capable of hair growth and surgical intervention may be required.

3. Traction Alopecia – we mention this possible option as, if you hair was long enough to warrant relaxing, it may also be the case that you often wore your hair pulled back off your face. Traction Alopecia can display as a receding hairline, often coupled with breakage, however, it is actually due to regular, excessive tension damaging the follicles. This leads to hair fall around the areas that bear the brunt of the strain, namely the hairline and temporal regions. Traction Alopecia treatment is available and the fact that you have stopped relaxing your hair and are hopefully wearing it naturally, not in tight hairstyles, should help the scalp to recover.

4. Male Pattern Baldness – this is an hereditary hair loss condition which affects the top of the scalp and presents as thinning hair and/or a receding hairline. Whilst often mistakenly associated with ageing, it can actually start to develop any time following puberty and is a permanent condition. It may simply be coincidence that you have started to notice the early signs of male hair loss at the same time you stopped using hair relaxers. Male Pattern Hair Loss Treatment comprising clinically-proven medications and non-pharmaceutical hair growth supporting products, can be used to help stabilise shedding, promote regrowth and prevent hair loss moving forward.

It is worth noting that it is possible to have any of these issues independently, or a combination of any – including, the worse-case scenario of all four. In cases of Chemical Trauma and Traction Alopecia, it is normal for hair breakage to be present as the chemicals and hairstyles weaken the hair, making it more susceptible. Afro hair is the most naturally brittle of all hair types, so can be particularly at risk.

If a genetic predisposition to male pattern hair loss is also active, this can exist simultaneously alongside any, or all, of these other issues. In most cases they can also be treated simultaneously, however, so the first step is to have a personalised diagnosis from a hair specialist, so that treatment recommendations can be made tailored to your precise requirements.


Circ - Male Pattern Baldness hair loss treatment Belgravia Centre clinic LondonThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert female pattern hair loss chronic telogen effluvium the belgravia centre 20 06 2018A new entry has just been added to Belgravia’s Female Pattern Hair Loss Treatment Success Stories gallery.

Miss P, pictured, is thrilled with the results of her treatment to date saying “After 3 months such great growth”.

Find out what else she had to say and see her regrowth results close up, or find out more about treating hereditary hair loss in women by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 

 


The Belgravia Centre Hair Loss ClinicThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Rugby Australia CEO, Raelene Castle arguably has a lot on her plate due to having the tough job of running the sport’s governing body, especially in a largely male dominated industry. So it is understandable that she wouldn’t want any additional distractions – such as a constant dialogue regarding her hair loss.

In an interview with ESPN Australia, Castle expressed sentiments echoed by many with the autoimmune disorder Alopecia Areata by sharing her story to raise awareness so that, by educating people, she can focus on getting her notoriously tough job done.

Raelene Castle

Empowering women in business

When I talked about it originally, I was concerned about three things: one, I didn’t want people to think I had cancer. Secondly, it’s not stress related — sure I could be healthier and do more exercise, but fundamentally that doesn’t make any difference — it’s just an autoimmune issue that my body has. Thirdly, I want to share my experiences with some young females in the business environment who are struggling with Alopecia,” Castle told ESPN AU.

As a woman, she understands how she can be judged somewhat differently to her male peers, with women’s appearances being far more significant to others – and harshy critiqued – than men in similar positions. As her particular type of autoimmune alopecia – which affects the scalp only – involves patchy hair loss with cycles of hair regrowth and relapse, she often covers her head with a bandana or scarf. This in itself has led to awful criticism and ignorant abuse from the rugby community, particularly on social media.

I think as a female you do get judged differently for what you wear and your appearance. People can be really cruel. At the end of the day I understand the issue, but people judging you for your appearance, saying ‘what are you, a pirate or a Muslim’ and those sorts of comments when they are uneducated to the issue that I face, is just one of those things.”

However, with a sensible head on her shoulders, Raelene Castle is getting on with the job in hand, not letting this deter her from the business of rugby. She is thrilled to have been able to inspire and empower other women in business who also have to deal with hair loss conditions.

I’ve had 40, 50, 60 women reach out to me and thank me for sharing my story, they’ve told me how it’s really helped them to think about how they might deal with it and how they can be honest about it — it’s been a really positive thing for me to do, to share my story and to help some other young women.”

Genetic element to Alopecia Areata

What is particularly interesting about Raelene Castle’s insight into having Alopecia Areata is that both she and her brother have the condition. Whilst hers is the mildest form and only affects her scalp, her brother has Alopecia Universalis which means he has no hair on his body from head to toe. This is the most extreme phenotype of Alopecia Areata.

Alopecia Areata treatment is available for the scalp form which Raelene has but there are no effective solutions for the form her brother has, as yet.

Whilst a number of triggers have been identified that can spark off Alopecia hairloss, including sudden shock and allergies, what is yet to be discovered is the condition’s precise underlying mechanism and what actually causes it. A genetic element has been suspected for some time, following various studies, though it has not been widely proven enough to be properly confirmed.


Circ - The Belgravia Centre Treatment for Hair LossThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 19 06 2018A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr G, pictured, is thrilled with the results of his treatment to date saying “I’m overjoyed with the results”.

Find out what else he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


In a move its star hopes will help to promote awareness, Bollywood movie Gone Kesh will feature a main character with autoimmune hair loss.

Haraamkhor actor, Shweta Tripathi will play a teen who wants to become a professional dancer and is diagnosed with Alopecia Areata. This is the most common form of hairloss worldwide behind Male Pattern Baldness and Female Pattern Hair Loss, and can affect men, women and children of all ethnicities.

According to Bollywood.com, it will be India’s first film based on the subject – though we can’t think of many Western films tackling this important subject either.

Shweta Tripathi alopecia hair loss bollywood filmEmotional journey

Tripathi (pictured), who is 32 years old, will portray the character’s emotional journey from finding out she has Alopecia Areata to how she then deals with it between the ages of 15 and 24. This is set to include the lack of understand her character faces regarding autoimmune alopecia, which is one of the reasons the former Disney Club series Kya Mast Hai Life star was drawn to the role.

This is an extremely special film to me. I had given my consent after reading just the synopsis as it intrigued me. I choose films when they strike a chord with me, and this one did and how,” Shweta Tripathi told Bollywood.com. “As an actor, to get the chance to play a part and pan out the journey of the character is thrilling. I feel movies made on social issues and not so well-known medical conditions always create an awareness in society. I know now what people with alopecia go through as some of them told me their stories.”

Types of Alopecia Areata

The phenotype of Alopecia Areata that Tripathi’s character will have has not yet been revealed. The condition causes sudden hair loss of different levels and in various locations depending on which type is present. Alopecia Areata – the name for both the over-arching group of conditions and the most mild form – affects the scalp only and causes rounded bald patches to appear. Though Alopecia Areata treatment is possible for this form, this is generally only for those aged 16 and over.

The more extreme phenotypes – Alopecia Totalis and Alopecia Universalis – present as baldness of the head, and total hair loss from head to toe, respectively. Whilst no treatment options currently exist for these versions, many are in development and it is currently hoped that a safe and effective hair loss solution will become available for these conditions by 2021.

In the meantime, children and adults may benefit from support from organisations who help to raise awareness of the condition, and what it entails. In the UK, hair loss charities such as Alopecia UK, Little Princess Trust and Hero by LPT do a great job of promoting knowledge surrounding these easily misunderstood issues, as well as providing tips for coping with Alopecia. It is hoped that Gone Kesh will further educate people about Alopecia in order to make life that little bit easier for those affected.


The Belgravia Centre Hair Loss Clinic - Hair Loss Specialist ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 15 06 2018 1A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr M, pictured, has seen an impressive improvement since starting his personalised course.

Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


It has traditionally been the case that men wanting to surgically restore their hair loss would have to wait until they were at least 30 years old, this being the recommended minimum age for a hair transplant.

Now, however, according to a presentation given at London’s FACE conference on 16th June by Dr. Mark Tam, “younger patients are also considering hair transplant as a treatment option to their early stages of hair loss, mainly receding hairline and temples in male pattern hair loss.”

Rooney Hair Transplant The Belgravia Centre for Hair Loss

Wayne Rooney after his first Follicular Unit Extraction hair transplant in 2011, which was followed up by additional work in 2013 (Image: Twitter/@waynerooney)

Dr. Tam queried whether the “traditional wisdoms of delaying treatment” were still appropriate. He advised that hair transplant surgery for a receding hairline and temporal areas could be used in conjunction with non-surgical hair loss treatments to potentially offer “substantial visual improvements” for men with early signs of Male Pattern Baldness.

Wayne Rooney Effect

A potential reason for this uptick in younger men going straight for the surgical route is that many will have grown up with hair transplants being a fairly common procedure. This is known as the ‘Wayne Rooney Effect’ due to the huge increase in visibility and interest for hair restoration surgery after the former England footballer openly shared his own journey via social media when he was 25 years old.

In the wake of reports concerning Wayne Rooney’s hair transplant, a huge surge of interest in the procedure was noted in a 2015 WhatClinic survey, with a 165 per cent boost in the UK alone. In Scotland, a 400 per cent increase in demand was noted and was also attributed to this phenomenon. Other celebrities, from James Nesbitt to Will Ferrell and numerous reality TV stars, have also been quick to share their own hairloss surgery stories, further encouraging an open diaglogue about how men deal with losing their hair – and keeping it.

As such, it has become increasingly commonplace for a once taboo subject to become not only de-stigmatised, but also something that men feel more comfortable discussing. Thanks to widespread international media coverage and a generation who grew up with the internet and social media, finding information about different options and hair loss solutions is easier than ever.

But, just as these technological tools provide great resources for finding out more about hair restoration, they also have a down-side. Various specialists have noted a rise in people’s insecurities as a result of selfie-culture, with more men – some as young as 16 – seeking hair transplant advice.

Not a quick fix

One reason younger men may be tempted to go straight to for the surgical option is the assumption that it’s a ‘quick fix’ for dealing with hair loss. Various other presentations at the FACE conference backed the theory that men are attracted to quick and easy solutions when it comes to their appearance.

For instance, Dr Anastasia Saybel, during her talk concerning why botox facial injections are currently the most popular anti-ageing treatment for men, gave the following insight: “Treatment with botulinum toxin is the most popular procedure among male patients. Why? The answer is obvious: fast, virtually painless, has no recovery period and has a gradually developing, noticeable effect. Generally speaking, for men it is crucial to see a desired result. We, women, are ready to make tests and experiments, while men agree to suffer a little bit from pain/injections but the outcome must meet their expectations“.

It is commonly assumed that getting a hair transplant is a one-off way of restoring hair and preventing baldness in future – so, perhaps worth going through a certain amount of discomfort and healing time for – but this is not actually the case.

The reason Male Pattern Baldness occurs is due to an active hereditary sensitivity to the testosterone by-product, dihydrotestosterone (DHT). This is useful as bodies develop sexual characteristics during puberty, but after this time it is largely redundant. What it does then is bind to the susceptible hair follicles, located around the top of the scalp from hairline to crown, and gradually weaken them over time. The rate at which these follicles are diminished varies from person to person but ultimately results in thinning hair, hair fall, and often eventual baldness in the affected areas.

During a hair transplant, follicles are harvested from areas of the scalp which are not vulnerable to the effects of DHT and replanted into the recipient site. What this means is that the transplanted hairs will be immune to DHT, however, the original surrounding hairs in the vulnerable areas will continue to suffer its effects. As such, it can be necessary to use clinically-proven treatments on an on-going basis in order to prevent hair loss around the grafts from this permanent genetic condition, and to preserve the overall look following surgery.

Anyone concerned about losing their hair who may be contemplating surgery is often advised to start this type of hair regimen at least six months prior to their op. The reasons for this are two-fold: firstly, to stabilise shedding and maximise hair growth which gives the surgeon more – and a cleaner area – to work with; and secondly, so a patient can ensure he is certain he wants to proceed with the transplant. Sometimes, after seeing their results from a pharmaceutical regime – often paired with key supporting hair growth products – men may consider delaying or even ditching plans for surgery, especially in younger candidates.


The Belgravia Centre Hair Loss ClinicThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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