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A team of researchers from different departments across The Catholic University of Korea, Seoul, have investigated cancer risks associated with the various phenotypes of Alopecia Areata.

This autoimmune disorder can affect different hair-bearing areas of the head and body, depending on the severity of the form. For instance, the mildest form – also known as Alopecia Areata (AA) – causes patchy hair loss of the scalp only, whilst Alopecia Totalis(AT)leads to total baldness of the scalp, often accompanied by the loss of facial hair, eyelashes and eyebrows, whilst the most extreme variation, Alopecia Universalis (AU) causes a person to become completely hairless from head to toe.

Other types of autoimmune alopecia can affect the beard area or the entire circumference of the hairline, however it was only the three key phenotypes outlined above which were considered in this June 2018 study.

Diagram Belgravia Centre Different Types of Alopecia Areata autoimmune hair loss

Areas affected by hair loss shown in blue

Increased risk of certain cancers

National statistical data was used to study the risk of cancers in people with Alopecia Areata, Totalis and Universalis, with the aim of establishing whether each individual phenotype of alopecia carried the same associations.

Researchers enrolled 668,604 patients who had been treated within the January 2007 to December 2014 period for one of these hair loss conditions. The participants were then separated into two groups by condition – AA or AT/AU – then by age and sex, and paired with a matched control volunteer without any form of AA in order to draw comparison data.

Risks were measured using hazard ratios (HR) – in this instance, the measure of how likely people with the various forms of alopecia were to develop cancer over a specific period of time – and confidence intervals (CI) – the defined range of values within which the likely value lies or, essentially, how likely the HR is to be correct.

According to the report’s findings, which were published in the Nature Research journal Science Reports on 27th June 2018 and make for interesting reading, all Alopecia Areata (1.022–1.065 HR), Totalis and Universalis (1.013–1.129 HR) had a slightly higher general risk of developing cancer than control participants. The CIs were reported as being 95 per cent in each case, providing a high level of certainty in the HR data.

No increased risk of developing some cancers, including lung, kidney, breast, pancreas, or skin cancer, lymphoma and leukaemia, was uncovered in any AA, AT or AU patients. However both groups demonstrated an higher propensity towards thyroid cancer, whilst scalp-only AA patients also had increased risks of bladder and prostate cancer.

Other health issues to monitor for

The Korean team concluded that ‘Careful monitoring is needed to explore if the actual risks of thyroid, bladder, and prostate cancers are increased in alopecia patients’.

This research follows other reports which have established links between additional health issues that people with all forms of Alopecia Areata may be more prone to, including other autoimmune disorders, dry eye disease, and mental health issues.


Circ - Belgravia Centre Hair Loss Clinics LondonThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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A woman from Manchester, UK, has spoken out about developing hair loss attributed to her horse riding hairstyles, and undergoing hair restoration surgery to correct the issue.

Samantha Dewhurst, a keen horse rider and the 2018 winner of TV reality show Survival of the Fittest, has been riding since she was seven years old and blames her receding hairline on the tight hairstyles required under helmets.

horse riding horse rider traction alopecia helmet hairstyles womens hair lossTight hairstyles

Dewhurst talked to the Daily Mail about tackling her receding hairline which appears to be the result of Traction Alopecia.

The 25 year old noticed her forehead was starting to appear larger in 2016 but managed to conceal it due to having a fringe.  After becoming self-conscious about her hairloss and avoiding things she loved doing, such as swimming, where her hairline may be exposed, she decided to take action.

Traction Alopecia is an entirely preventable hair loss condition which occurs when hairstyles which add extra weight or tension – usually hair extensions, taut braided styles or any hairstyle which requires the hair to be scraped back and tightly secured – place excessive tension on the hair follicles. In addition to causing hair breakage, when these problematic styles are worn often they can cause hair loss which, if not caught in time, can be permanent.

The condition can be found among athletes who have to wear their hair in strict regulation hairstyles, including horse riders like Samantha Dewhurst, and – most commonly – ballet dancers, hence the condition’s nickname ‘Ballerina Baldness‘.

Non-invasive Traction Alopecia treatment is possible in many cases, as long as the cause of the tension is removed to allow the follicles to recover. At Belgravia this involves a personalised course comprising topical medication alongside various key hair growth supporting products.

Once the areas affected, most often the hairline and temporal regions as these bear the brunt of the strain, have developed a smooth, shiny appearance this is a sign that the follicles are no longer capable of healthy hair growth. As such, hair restoration surgery is generally the only option but this is decided upon by the surgeon in each instance as there are many factors to consider in cases of women’s hair transplants.

Long hair restoration process

Dewhurst took the surgical route and had a hair transplant involving around 900 grafts. The hair follicles which were implanted into her receding hairline areas – known as ‘donor hair’ – were taken from the back of her head. In women, especially in cases of Female Pattern Hair Loss where there is more generalised hair thinning, enough good quality donor hair can be hard to find, though this is less likely to be a problem in cases of Traction Alopecia. This donor hair was harvested and re-grafted using an ARTAS robot.

Speaking about the procedure, which took place in a Birmingham clinic, Dewhurst told The Mail, “It was nerve-wracking. It was quite a daunting experience, but everyone was lovely… I had local anaesthetic around the neck and the back of the head, where they extracted the hair from. That was probably the most painful bit. They then extracted the hair, and once they did that they checked the grafts to see how feasible it was to put them back in. I had more local anaesthetic in the area at the front, where they were going to put the hair into.”

It will take around 12 months for the blogger to see the full results of her hair transplant but she noted that, despite it being a long process, she is pleased to finally be seeing hair starting to grow in the previously barren area.

Anyone concerned that they are experiencing unusual levels of hair fall, sudden hair loss or issues such as a receding hairline or drop in hair density is advised to take professional advice from a hair specialist as soon as possible. That way a diagnosis, advice and treatment recommendations, where needed, can be provided in a timely manner allowing for an informed decision to be made as to the most suitable hair loss solution.


circ - Belgravia Centre Hair Loss Clinic Laser TherapyThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert female pattern hair loss the belgravia centre 11 07 2018A new entry has just been added to Belgravia’s Female Pattern Hair Loss Treatment Success Stories gallery.

Ms S, pictured, is thrilled with her experience to date saying “got my confidence back, I feel happy, not down anymore.”

Find out what else she had to say and see her regrowth results close up, or find out more about treating hereditary hair loss in women by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


The Belgravia Centre Hair Loss ClinicThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


As any film from The Fast and the Furious franchise proves, there are many men for whom baldness is a great look. But, for others, going bald is not something to embrace as wholeheartedly as Vin Diesel, Tyrese or Dwayne ‘The Rock’ Johnson.

One reason some men can be uncomfortable about losing their hair is due to some of the perceived negative associations that surround hair loss.

In addition to – incorrectly – being considered a sign of ‘old age’, according to a report in the British Journal of Dermatology, baldness is also used in children’s animated films as a ‘visual shorthand for negative traits’. In short, we are taught from a young age that baddies are bald, which is where early negative connotations can start.

On-going reinforcement of negative stereotypes

Child watching TV television film movie cartoon animationPublished in June 2018, the University of Texas study considered the morality and visual dermatological attributes of key human characters from the top 50 highest grossing animated movies up to January 2017. Half of the films reviewed were released after 2010. Films where the characters were animals or robots, or where there was a PG-13 rating, were excluded.

It found that a number of dermatological issues, including baldness, wrinkles, scars, moles and spots, were used to signify how ‘bad’ a character was in 76.5 per cent of the animations studied. Only 25.9 per cent of ‘good’ characters shared any of these traits.

This backs previous findings from a 2017 clinical evaluation of movie villains which also found hair loss to be a top trait, showing how this stereotyped view may start in childhood and be subconsciously reinforced throughout people’s lives.

Destigmatising baldness

This stigmatisation does not just apply to men with Male Pattern Baldness, of course; it also refers to men, women and children with hairloss from the autoimmune disorder Alopecia Areata.

This can cause anything from treatable patchy hair loss anywhere on the scalp, to complete baldness of the head – including facial hair, lashes and eyebrows, to the body rejecting all hair from head to toe in the most extreme form. These latter two conditions, Alopecia Totalis and Alopecia Universalis, cannot currently be effectively treated though it is hoped that at least one of the many autoimmune hair loss solutions in development will become available for prescription in around the year 2021.

For people affected by any of these hair loss conditions, combating long-held misconceptions can be an upsetting experience, so the American researchers and the British Association of Dermatologists have called for film-makers to do better.

The depiction of skin issues in movies and its association with evil over good could be a factor contributing to the stigma of skin disease,” commented Michael Ryan, one of the researchers involved in the study. “Societal perceptions and beliefs regarding beauty and youthfulness are likely underlying the desire [for treatments]. The association between evil and skin findings in film could be one factor that contributes to these beliefs.

British Association of Dermatologists’ Communications Officer, Matthew Gass also noted, “The animated films we watch as children tend to stick with us, with many of us being able to fondly recall our favourites with ease. We watch them in formative years when we are learning about good and evil, and whether they mean to or not, it’s likely that they impact our biases and associations. One thing that thing that we know is that the creators of these works are capable of producing emotional, nuanced, and thoughtful works. We hope that this means that they will be open to considering this research when making animated films in future.”


The Belgravia Centre Hair Loss Clinic - Hair Loss Specialist ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 09 07 2018A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr M, pictured, is seeing improvement in all thinning areas since starting treatment.

Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 

 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


It has long been established that people diagnosed with one autoimmune disorder are more prone to additional autoimmune diseases. However, a link has also been suspected between psychosis and non-neurological autoimmune disorders.

One of the conditions this includes is Alopecia Areata, which can affect men, women and children, and involves the body turning on its own hair follicles. It has various phenotypes which each present in increasing degrees of hair loss, from rounded bald patches on the scalp only, to baldness of the head, or from head to toe.

brain psychology psychosis mental healthAccording to Psychology Today, previous Taiwanese and Danish studies had found schizoprenia to be more common in people with certain non-neurological autoimmune disorders, including Alopecia Areata. With the presence of such an autoimmune disorder estimated to potentially increase the risk of schizoprenia by 30 to 45 per cent.

Now, new data from King’s College London and the National Institute for Health Research in the UK disputes this in relation to autoimmune alopecia.

‘No significant associations’

Meta-analysis research detailing the findings was published in the Biological Psychiatry journal on 28th June 2018. The study involved reviewing data for more than 25 million people taken from 31 studies which were performed prior to or in April 2018.

A positive correlation between non-neurological autoimmune disorders and psychosis was established, but the propensity varied dramatically depending on the disorder. It showed that both conditions could occur simultaneously, as well as finding that psychosis could increase the risk of developing non-neurological autoimmune disorders – or vice versa.

Whilst those showing most consistent links with psychosis were listed as being pernicious anaemia, pemphigoid, psoriasis, coeliac disease and Graves’ disease, the research paper states that ‘no significant associations with psychosis were observed for alopecia areata’.

Study authors speculated that, ‘specific factors, including distinct inflammatory pathways, genetic influences, autoantibodies targeting brain proteins, or exposure to corticosteroid treatment’ may underlie any positive association between non-neurological autoimmune disorders and psychosis. They recommend monitoring at risk patients for early signs of psychosis and psychotic disorders such as schizophrenia.

Mental health and alopecia areata

Due to the sudden onset and highly visible of all forms of Alopecia Areata, it is often associated with mental health struggles, including anxiety and depression. Even England Rugby player Heather Fisher, known for her mental toughness on the pitch, has spoken openly about finding her baldness hard to cope with sometimes.

Whilst Alopecia Areata treatment can be used by over 16s with the scalp-only form, those with the more extreme variations – Alopecia Totalis and Alopecia Universalis  – have no safe and effective options as yet.

Though wigs, hats and scarves may provide temporary respite, professional counselling can be useful in helping people to come to terms with losing their hair. By learning strategies and coping mechanisms for dealing with both their own and other people’s reactions to their baldness, people affected by hairloss can often become more confident. Anyone interested in taking this route should speak to reputable specialists to whom they can usually be referred or recommended by their doctor, dermatologist or by charities such as Alopecia UK.


Circ - Minoxidil iconThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 09 07 2018A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr A, pictured, is showing solid signs of improvement after his first three months.

Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Whilst still very much in the minority, it seems to be a little known fact that women wanting to address their hair loss can have hair transplants as well as men.

Interest in surgical hair restoration among women is on the rise, but reality TV star, Maria Fowler provides a cautionary tale on not rushing into this type of procedure without proper research and preparation.

Maria Fowler and Kelvin Batey

Maria Fowler and Kelvin Batey after their first hair transplants in September 2017

We had previously suspected Traction Alopecia caused by frequently wearing tight high ponytails and hair extensions, as the reason behind the former TOWIE star’s first hair transplant. However, she has revealed that her reasons were cosmetic rather than due to her having a hair loss condition.

It appears she had wanted her hairline reshaped, or possibly lowered, but it ended up being a huge mistake.

Second hair transplant to correct unnatural hairline

Maria Fowler told the Daily Mail that after having her first hair transplant, she was left devastated and self-conscious by an unnatural looking hairline.

The first clinic didn’t use selection techniques when it came to selecting the finer strands for my hairline, and as a result, I’ve spent the last nine months feeling awful… I completely regret it,” she told the newspaper.

The 31 year old has just undergone a second hair transplant to correct the problems from her first op, which had been part of a His ‘n’ Hers deal she and her partner, BMX pro Kelvin Batey underwent in September 2017. She says his receding hairline now looks “OK“, though hers required the second corrective surgery to give her resulting blunt hairline a more natural appearance.

After going through what is an undoubtedly stressful, not to mention expensive, process, with a further nine months or so of healing ahead of her, the mum of one wanted to encourage people to do their homework before considering hair restoration.

I want to stress the importance of choosing the right clinic, people need to do their research and read reviews… I want people to take note and learn from my mistakes, there’s so many forums for hair loss, there’s a big community with people who are educated. You need to get the right advice because I was so naïve,” Fowler warned Mail readers. This is extremely good advice and something we support wholeheartedly.

Women’s hair loss treatment options

Andrea Twitter Traction Alopecia Female Pattern Hair Loss Treatment Success Story Tweet Belgravia Centre

For women seeking to change the natural shape of their hairline, surgery is currently the only option. But for those with thinning hair or receding caused by medical hair loss conditions, there are non-invasive solutions available.

How, or even if, a woman decides to deal with her hair loss is such a personal decision that it should not be rushed; it is so important that every client feels comfortable with how they want to proceed.

Belgravia hair specialists always advise anyone concerned about losing their hair, or experiencing sudden or excessive hair fall, to have a consultation either in-person at a dedicated hair loss clinic, or online where they can be assessed remotely. This free service can provide – at the very least – the relief and reliable information that comes with getting a professional diagnosis and understanding exactly what is happening and why.

From there a personalised hair loss treatment course tailored to the individual’s pattern and level of shedding, medical profile and lifestyle needs can also be recommended. Whilst starting treatment may be daunting for some, Belgravia clients often tell us that when they start to see results, it spurs them on to be extra diligent about using their treatment and hair growth supporting products. Many also cite having the constant support of dedicated hair experts who can answer any queries along the way as being a valuable part of their course.

As Female Pattern Hair Loss and Traction Alopecia treatment client Andrea tweeted along with the photo collage pictured, “I am speechless, from bald patches to healthy hair! Thanks @belgraviacentre now 15 months later, thanks Trinity [her personal Treatment Advisor], thanks belgravia centre, after years of trying everything.


CIRC Hair Vitalics for Women hair growth supplements Belgravia Centre womens hair loss treatmentThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 06 07 2018A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr D, pictured, is thrilled with the results of his treatment to date saying “Worth the investment and would recommend!!”

Find out what else he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Some promising news has been released regarding the topical hair loss treatment being developed for two currently untreatable autoimmune disorders: Alopecia Totalis and Alopecia Universalis.

Late on 9th July 2018, Aclaris Therapeutics, Inc. – the pharmaceutical company behind the drug, known as ATI-502 – announced the Food and Drug Administration (FDA) has granted the treatment a Fast Track designation.

This means that the organisation will work with Aclaris, with its clinical trial results and findings in relation to this topical hair loss solution being considered as a priority by the American regulatory body – the US equivalent of the UK’s MHRA. As such, it is likely to proceed as quickly as possible to the approval stage needed to become widely available for prescription use.

food-and-drug-administration-usa-fdaPromising results for ATI-502

Only days ago we reported on the positive outcomes noted in the primary data released from the current Phase 2 clinical trial for ATI-502. It showed that the first six patients using the topical drug had absorbed ATI-502 well with no reported side effects over the initial 28 day period, nor the following six month phase.

Most encouragingly, Aclaris released research notes which stated that the treatment demonstrated an ability to modify the genetic signature of these severe forms of Alopecia Areata. As the precise mechanisms involved in all forms of these autoimmune hairloss conditions is relatively uncertain, this presented a potentially significant breakthrough for both understanding these disorders, as well as learning how to treat them.

Currently there are only Alopecia Areata treatment options with meaningful success rates for the scalp-only form which presents as rounded bald spots or patches. Alopecia Totalis presents as baldness of the entire scalp as well as facial hair loss, including losing eyelashes and eyebrows, whilst Alopecia Universalis causes the entire head and body to become smooth and completely hairless. Whilst some, usually steroid-based, Totalis and Universalis treatments are available, none have significant success rates, making them largely futile.

Second treatment to be FDA Fast-Tracked

With the development of Janus Kinase inhibitors – more commonly referred to as JAK inhibitors – as potential hair loss treatments for autoimmune alopecia, drugs such as ATI-502 have started to bring the dream of a truly effective treatment closer to reality.

This is not the only medication to have been fast-tracked by the FDA for these conditions, either – Concert Pharmaceuticals announced its oral tablet CTP-543 had received this designation in January 2018- doubling the chance of this long-awaited development coming to fruition.

Current estimates suggest that the first JAK inhibitor, or JAK inhibitor-inspired treatments for Alopecia Areata in all its phenotypes, should be ready to release in around three years time, in 2021. This is assuming the remaining phases of each drug’s clinical trials go to plan and meet the necessary criteria regarding safety, efficacy and tolerability, for the relevant FDA approvals and MHRA licences to be granted.


The Belgravia CentreThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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