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According to a March 2019 article in Dermatology Advisor, people treated with cytotoxic chemotherapy may experience more severe, diffuse persistent hair loss than cancer patients who undergo endocrine-based therapy after chemo.

A retrospective evaluation was carried out as part of a study published in the JAMA Dermatology journal, looking at the treatment outcomes, quality of life and the ‘effect of dermatologic therapy’ of 192 female cancer patients who developed persistent hair loss from chemotherapy. The most common type of cancer among the women studied was breast cancer.

Chemotherapy Induced Alopecia

It was noted that 98 of the 192 developed persistent chemotherapy-induced hairloss, while 94 experienced endocrine therapy-induced hairloss following chemo.

Whilst 82 per cent of the study participants with persistent chemotherapy-induced alopecia had been treated with taxane-based chemotherapy, 20 per cent fewer had undergone endocrine therapy-induced hair loss after chemotherapy that was treated with aromatase inhibitors.

As the Dermatology Advisor article states, “Those with persistent chemotherapy-induced alopecia had more diffuse alopecia (41% vs 25%; P =.04), a higher frequency of a Common Terminology Criteria for Adverse Events severity score over a grade 2 (39% vs 13%; P <.001), a lower mean number of hair shafts per follicular unit (1.3 vs 1.5; P <.001), and lower mean numbers for hair thickness (62 [13 μm] vs 68 [13 μm]; P =.02) when compared with those with endocrine therapy-induced alopecia after chemotherapy.”

What causes hair loss from chemotherapy?

Belgravia hair loss specialist, Rali Bozhinova explains, “Chemotherapy affects the cell division (mitosis) and aims to slow it down or stop it. So, when patients experience hair loss from chemotherapy, it is because cells in the hair bulb stop dividing and, therefore, the hair stops growing.

This is called Anagen Effluvium and only affects the anagen hairs – the ones which are actively growing at the time chemotherapy starts.

Anagen Effluvium can sometimes cause all anagen hairs to fall out; this is approximately 90 per cent of all of scalp hair, leaving the patient looking bald.

Paxman Scalp Cooling Cold Cap to Help Prevent Hair Loss During Chemotherapy

Unlike in cases of hair loss conditions such as Androgenetic Alopecia – Male Pattern Baldness and Female Pattern Hair Loss – or Telogen Effluvium, these hairs don’t fall out from the root – with their bulb – instead they break. As such, once the patient’s chemotherapy course has been completed, the cell division in the remaining bulbs resumes, thus the hair starts regrowing from the exact same bulbs.”

Hair fall may be minimised during chemotherapy in some cases by wearing a scalp cooling device, commonly known as a cold cap. This is worn during chemo sessions and helps to prevent hair loss by chilling the scalp to extremely low temperatures, discouraging the circulation of chemo drugs to the scalp and hair follicles.

Hair regrowth after chemotherapy

Once the last session of chemotherapy has been completed, hair growth can resume naturally within a few months, though it may take around 12 months for the hair to return to looking more like its pre-cancer state.

Bozhinova explains the reason for this as being, “Because hair is growing from the same bulbs, hair regrowth after Anagen Effluvium can start very quickly, but it may take long time – around 12 months or so from the last chemo session – for the hair to return to its natural thickness, density and/or quality.”

Hair growth after chemotherapy can sometimes throw up surprises, such as a change in hair texture or colour, but this is generally a temporary issue that rights itself naturally.

Hair specialists are often asked by cancer survivors about hair regrowth treatment after chemotherapy; whilst this is not usually necessary, patients are welcome to have a consultation and hair loss solutions can be recommended based on their findings and the individual’s medical profile.

However, it is Belgravia Centre policy that hair loss treatment will not be provided without prior written confirmation from the patient’s oncologist or doctor confirm they are suitable and happy for them to go ahead with the relevant course components.


Circ - Belgravia Centre Hair Loss Clinics LondonThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

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(Results may vary and are not guaranteed)

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Circ - Belgravia Centre Hair Loss Clinics LondonThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Name: Gavin

Question: I’ve been using hair loss treatment for male pattern baldness for 1.2 years and it’s been going well but now I’m shedding more hair than I used to before I started treatment – is this normal? I want to know can you still lose hair when you use minox, fin and nizoral or does it mean my treatment isn’t working any more. Thanks.

Hair Growth Cycle

Answer: Hi, Gavin. Everyone, regardless of whether they have a hair loss condition or not, sheds hair regularly.

This is simply a regular part of the hair growth cycle whereby older hairs are constantly being replaced by newer ones. It is normal to lose up to 100 or so hairs per day without there being any need for concern.

We would need further information regarding the hair loss you are currently seeing in order to provide you with a confirmed diagnosis and recommendations so having a consultation either in person or online, would be beneficial to get a more accurate, personalised answer. For now, however, we can give you some general advice to your query.

You note treating your Male Pattern Baldness with a combination of the only two clinically-proven male hair loss treatments, minoxidil and finasteride 1mg. As Nizoral is simply a shampoo it is unlikely to have any significant effect on your hair growth.

Finasteride 1mg inhibits the formation of DHT, which is what causes the thinning hair and drop in hair density symptomatic of Male Pattern Hair Loss. High strength minoxidil promotes accelerated, localised hair growth. This can extend the active growth phase of the hair cylce, but does not prevent normal shedding from occurring.

Hairloss treatment Male Pattern Baldness Lasercomb

Whilst shedding is possible when you first start using minoxidil and/or finasteride, as you have been on your current course for over a year, this is not applicable here.

In many cases, every day hair fall is barely noticeable so the fact you are aware of this and believe you are shedding a considerable amount suggests there may be another factor at play beyond genetic hair loss.

The first thing we would have you look for is where the hair is shedding from – is it just the top that is affected or is it the whole scalp? Secondly, think back to anything unusual which may have taken place around three months ago, particularly any illnesses, accidents or stressful life events.

Male Pattern Baldness only affects the area of the scalp along the vertex (top) from hairline and temples to crown, however, temporary hair loss conditions such as Telogen Effluvium cause diffuse shedding from the entire scalp.

Whilst it may appear to come on suddenly, Telogen Effluvium, which can affect over 30 per cent of scalp hairs and tends to last for no longer than six months, is generally triggered three months prior to hair fall becoming noticeable.

The most common cause of this temporary shedding is stress; this can be emotional or physical, including issues such as dietary imbalances, nutritional deficiencies, an underlying illness, accident, or surgery.

This type of temporary hairloss can present simultaneously alongside Male Pattern Baldness or on its own, and should clear up naturally within a few months.

Another potential issue that can cause excessive hair fall is seasonal shedding. Although this tends to happen during the winter months, it can also happen at other points during the year and, again, rights itself without any need for intervention.

As before, the best way to find out exactly what is behind your current shedding is to have a hair loss specialist examine your scalp or conduct an online consultation using photos. They can then determine what is the cause and whether your current hair loss treatment regimen is appropriate for your situation.


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

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(Results may vary and are not guaranteed)

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Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Name: Rick

Question: Hi, I noticed recently that around 30% of the hairs I shed are thin and short. I don’t shed a lot of hair but the hairs I shed have different pigmentation. Is this the early sign of MPB? I’m pretty sure I have MPB but based on the above symptom, when do you think I should start taking action? My hair is still thick and my hair line is still good (receding a bit in the right side and miniaturize).

Answer: Hi, Rick. I advise you to start by having a consultation with a hair loss specialist or dermatologist who can thoroughly examine your scalp and hair and provide you with a professional diagnosis.

It is always wise to determine exactly what is causing any hair loss or drop in volume so that a suitable treatment course can then be recommended.

Hair Loss Consultation Trichocheck at The Belgravia Centre

If you do have Male Pattern Baldness (MPB), it is best to start treatment as early as possible. This is a genetic condition which can start any time after puberty in those with the relevant predisposition. It is caused by a male hormone called dihydrotestosterone (DHT) which gradually makes the genetically-predisposed hair follicles to shrink through a process called follicular miniaturisation.

The miniaturised follicles produce increasingly thinning hair over time, then eventually lose the hair completely and the follicles disappear. This is when hair loss turns to permanent baldness; when the follicles reach this stage they are no longer capable of producing healthy hair growth.

Belgravia specialists find that, if you are hoping to prevent baldness, the earlier you start hair loss treatment, the better results you can achieve. Once you lose the hair follicles, and baldness sets in, they cannot regrow hair and it is too late to address the problem.

With regard to the pigmentation issue you mention, the thinner hair strands from the miniaturised follicles may appear lighter in colour. This does not mean that there is any problem with your melanin production – the process by which natural hair colour is determined – they are simply very thin hairs with less bulk in the cortex.

If you look at your vellus hair covering your body, it also appears lighter in colour than the longer hairs on your scalp, known as ‘terminal hair’. However, Male Pattern Hair Loss does not affect the hair pigment.

On the other hand, if there is any pigment change in your hair, it is important to be discussed with a dermatologist as it may be unrelated to the hairloss you mention.

For example, vitiligo is an autoimmune disorder which affects the cells producing melanin, known as melanocytes. This can leave areas on your skin, including the scalp, without any pigment. It can sometimes affect the hair too, but this condition does not cause hairloss.

If you have had Alopecia Areata – an autoimmune disorder which causes patchy hair loss to appear suddenly – the regrowth from this can be lacking pigment and appear white or cream. Again, this is unrelated to Male Pattern Baldness, but it is possible to have both conditions at the same times.

As before, a consultation with a hair expert will help you to determine exactly what is going on, with regards to identifying any hair loss condition and/or scalp issues. Recommendations for suitable treatments or courses of action that can be taken will then be made based on their findings, as well as your medical profile, and they can answer any further queries you may have.


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

A new entry has just been added to Belgravia’s Female Pattern Hair Loss Treatment Success Stories gallery.

Find out what this client had to say and see her regrowth results close up, or find out more about treating hereditary hair loss in women by clicking the buttons below…

(Results may vary and are not guaranteed)

VIEW SUCCESS STORY

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The Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

Concert Pharmaceuticals has announced a second open label clinical trial into a form of its novel oral treatment for Alopecia Areata, CTP-543 is due to start soon.

This will concentrate on a one-a-day 24mg dose of CTP-543 and will compare results to 12mg twice-daily doses, taken by separate, randomized groups over a 24 week period.

Each of the 60 patients taking part across the USA and Canada will have a confirmed diagnosis of hair loss from Alopecia Areata, Alopecia Totalis or Alopecia Universalis.

These are the key forms of the autoimmune disease Alopecia Areata, which presents as patchy hair loss to the scalp only (Alopecia Areata), total baldness of the head, often including a loss of eyelashes, eyebrows and facial hair (Alopecia Totalis), and complete hairlessness from head to toe (Alopecia Universalis).

Pills medication tablets

Whilst not exactly a JAK inhibitor itself – the suite of drugs currently leading the race to produce the first authorised, MHRA-licensed and FDA-cleared treatment for all forms of Alopecia Areata – CTP-543 is a deuterium modified version of the Janus kinase 1 and 2 inhibitor, ruxolitinib (brand name, Jakafi).

Complementary trial

This new trial – which is currently estimated to complete in April 2020 – has been designed to complement Concert’s first open label trial of CTP-543. Findings should help researchers to determine the drug’s optimal dosing, providing the basis of doses to be tested further in additional clinical trials.

The first study, which began in March 2019 and is due to complete later in the year, involves participants receiving oral CTP-543 doses of either 8 mg twice per day or 16 mg once each day, for a total of 24 weeks.

Both trials will compare patients’ baseline and 24 week-mark Severity of Alopecia Tool (SALT) scores in order to determine the drug’s – and dose’s – efficacy.

“Our aim is to optimize the dosing regimen for CTP-543, so that we can best meet the needs of patients with this autoimmune disease for which there are currently no FDA-approved treatments,” said James V. Cassella, Ph.D., Chief Development Officer of Concert Pharmaceuticals, via a company press release.

Interim CTP-543 phase 2 trial results

The most recent update as to how the current CTP-543 trials are going, was provided at the March 2019 American Academy of Dermatology (AAD) Annual Meeting, where promising interim results were disclosed from an ongoing Phase 2 trial.

Concert Pharmaceuticals’ CTP-543 has received Fast Track designation from the FDA, along with two other companies also developing potential hair loss solutions – oral and/or topical – to address mild to severe Alopecia Areata.

food-and-drug-administration-usa-fda

Due to the significant emotional and psychological effects these various forms of sudden hair fall can cause, and the fact no FDA-approved – nor MHRA-licensed – hairloss treatment for these specific conditions yet exists, the FDA is hoping to help speed up the process for developing treatments by working closely with the most promising candidates.

The earliest likely release date for any of these novel hair loss solutions is estimated to be 2021-22.

In the meantime, Alopecia Areata treatment is available for adults with the scalp-only phenotype, and a personalised course can be recommended following a consultation with a hair loss specialist.

Adults with more extensive baldness, or children with any form of Alopecia, are advised to contact their GP or dermatologist as a first port of call. Hair loss charities can also provide invaluable help in the form of free wigs, contacts for suppliers and local or online peer support groups.

However, hopefully, we are now closer than ever to there being a realistic treatment option for those who have lost their hair to conditions as severe as Alopecia Universalis, and would love to have it back again.


The Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

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Find out what this client had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

VIEW SUCCESS STORY

Treatment information


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Name: Brenda

Question: I just realised I’ve nearly run out of minoxidil I’ve been using to treat my female pattern baldness. I bought a year’s worth in November and now it’s nearly June and I’ve only got a couple of weeks worth left. I don’t feel like I have side effects or lots of regrowth, my hair is maybe a bit less thin but it’s still not as thick as it used to be. Can I keep over-using minoxidil or should I start using the right dose now? I can’t really only use the right amount because it doesn’t cover my whole scalp so if I really do have to use the proper dose can you advise me how to make it cover everywhere?

Applying-Minoxidil-For-Women-hair-loss-treatment-Belgravia-Centre

Answer: Hi, Brenda. Thanks for your queries, over-using medication is never a good idea and certainly not something Belgravia would advise, but let’s address each of your concerns in order…

Firstly, you mention you have female pattern baldness – we would query if this is a professional diagnosis?

You also say you bought a year’s worth of minoxidil so, as the specialist pharmacies in each of our hair loss clinics do not dispense 12 months of high strength minoxidil in one go, we are assuming you are using over-the-counter products without the support or supervision of a trained advisor.

If you have self-diagnosed your hair loss condition, it is certainly worthwhile having an expert assess you as you also mention having to apply your treatment to your ‘whole scalp’; this is not the case for women with Female Pattern Hair Loss.

There are also numerous reasons for thinning hair in women, so it’s important to first know exactly what you are dealing with.

When using any medication – including hair loss treatment – it is crucial to follow the instructions provided to the letter. Over-using drugs will not make them work better or faster, but it may lead to an increased risk of side effects.

Just because you have not experienced any adverse reactions from over-using minoxidil just yet, this does not mean you will continue to be symptom-free.

We highly recommend you drop down to the recommended dosage and use your treatment exactly as stated on the product, or its packaging or patient information leaflet, from now on.

With regards to having the medication cover your scalp, the affected area in cases of genetic hair loss is the top of the scalp – from hairline and temples to crown – only. As such, there is no need to apply minoxidil to other areas of your scalp.

If your hair loss condition is confirmed as androgenic alopecia and you still find this area to large to cover with the recommended dose, we advise one of two things…

Firstly, you can either try your best to cover the relevant areas of your scalp and, for example, if you feel you didn’t get quite enough coverage in one area, such as the crown, that time, the next time you apply your dose, ensure this area is properly covered on the next application. You can repeat this process each time.

Secondly, you may find it easier to ensure proper coverage if you switch to a different formulation eg. from a foam to a liquid, so this is also worth trying if you are still having difficulty with your applications. However, you must stick with the recommended dose and must not use two different formulations at one time.

If you are concerned that after the six or so months you have been using minoxidil that you are not seeing the results you had hoped for, it may be that you are not using the right mix of female hair loss treatments for your level and pattern of shedding.

In addition to checking you are using the optimum formulation of minoxidil, a hair loss specialist can also recommend additional hair growth supporting products which you could add in to your existing hair regimen and may find beneficial.

These range from FDA-cleared low level laser therapy devices, such as the LaserBand, which has been shown to stimulate the follicles, helping to promote strong, healthy hair growth, to highly-targeted one-a-day food supplements.

Even if you later decide not to go ahead with these additional options, we still believe it is worthwhile checking in with an expert so they can assess your scalp and ensure you are using the correct treatment and optimum dose for your condition and medical profile.


Circ - Belgravia Centre Hair Loss Clinics LondonThe Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.

Related Stories


Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

A new entry has just been added to Belgravia’s Female Pattern Hair Loss Treatment Success Stories gallery.

Find out what this client had to say and see her regrowth results close up, or find out more about treating hereditary hair loss in women by clicking the buttons below…

(Results may vary and are not guaranteed)

VIEW SUCCESS STORY

Treatment information


The Belgravia Centre

The Belgravia Centre is an organisation specialising in hair growth and hair loss prevention with two clinics and in-house pharmacies in Central London, UK. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the world. View our Hair Loss Success Stories, which includes the world’s largest gallery of hair growth comparison photos and demonstrates the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time to arrange a free consultation.