Minoxidil + MPG / Azelaic Acid / Caffeine
How Minoxidil Helps Reduce Hair Loss and Increase Hair Growth
Whilst minoxidil encourages hair growth and hair loss stabilisation, the exact molecular mechanism operating in the cells that result in hair growth from Minoxidil is not known. Some experts believe that minoxidil dilates the blood vessels around hair follicles, increasing the nutrient supply and encouraging increased hair growth, however, this is still an unproven theory, as vasodilator drugs other than Minoxidil do not appear to promote hair growth.
Another theory is that topical Minoxidil induces a significant increase in DNA synthesis in hair follicle cells. Minoxidil is a stable and inactive drug. When applied to the scalp and absorbed into the skin Minoxidil is converted to an active, unstable product called ‘Minoxidil Sulphite’. Our body produces a catalyst called sulfonyl transferase that converts the inactive Minoxidil into the unstable active Minoxidil Sulphite. Minoxidil sulphite activates potassium channels in cells and this is thought to lead to hair growth.
Whilst there is no conclusive evidence as to why Minoxidil encourages hair growth, the fact is that it does, be it to varying degrees.
What is Medroxyprogesterone?
Medroxyprogesterone (MPG) can be found in our Minoxidil 4%, 5% and 8% solutions depending on the recommendations of the Belgravia hair specialist for each individual. The aim of MPG is to help to prevent dihydrotestosterone (or ‘DHT’ – which is the product in the body that causes genetic hair loss) from destroying the hair follicles. This complements Minoxidil’s reaction with the follicles, and may add to the response that is achieved. When MPG is added to Minoxidil it becomes a prescription-only treatment but in many cases Minoxidil will be provided without MPG contained.
What is Azelaic Acid?
Azelaic Acid (AA) is added to Belgravia’s 10% or 12.5% Minoxidil cream and can in some cases be used as a substitute to MPG in our liquid minoxidil formulations for patients that are not suited to MPG. Azelaic Acid is added to minoxidil with the aim of reducing the amount of DHT reaching the hair follicles by inhibiting the formation of 5-alpha reductase. 5-alpha reductase is the enzyme that combines with testosterone to form dihydrotestosterone, which in turn causes genetic hair loss.
Why Might Caffeine Help Prevent Hair Loss?
Studies have shown that caffeine could be an effective blocker of the DHT hormone locally around hair follicles. In one particular lab study, hair follicles were removed from balding men and exposed to testosterone. Some were also exposed to caffeine. The hair growth from follicles exposed to testosterone was significantly reduced (as is the case with follicles affected by Male Pattern Hair Loss) whereas not only did caffeine seem to prevent testosterone from negatively affecting hair growth, but it also stimulated growth of the hair.
Getting the Best From Minoxidil
Belgravia hair loss specialists have found that whilst Minoxidil can help reduce hair loss and boost hair growth, the degree of success will often depend on the Minoxidil’s strength. The Minoxidil formulations that we provide for men vary from a mild 5% Belgravia or Regaine lotion, to an extra-strength 8% liquid formulation. Belgravia also produces minoxidil in a 10% or 12.5% cream, used to treat very stubborn patches of thinning hair and baldness. Depending on what is recommended to the individual hair loss sufferer, we can also provide Minoxidil containing the extra boosters Medroxyprogesterone (MPG), Azelaic Acid and/or Caffeine.
Medical experts have also found that treatment for male pattern hair loss can be further enhanced by combining the use of Minoxidil with Propecia , which is the most recent clinically proven and medically approved drug for hair loss. Courses consisting primarily of Minoxidil and Propecia are the most popular and successful treatment combinations prescribed at the Belgravia Centre. Click on the link to find all you need to know about Propecia .
A Belgravia hair loss treatment course consists of more than just Minoxidil or Propecia, we find that ‘treatment courses boosters’ are just as important. Find out about treatment course boosters and how a Belgravia hair loss treatment course ensures the highest likelihood of hair re-growth.
Like most other drugs there can be side effects from the use of Minoxidil. Side effects from Minoxidil are unlikely and are usually mild. Some of the possible side effects are increased facial hair growth, headaches, rashes and palpitations. Side effects should diminish in a short time during use of Minoxidil or shortly after stopping Minoxidil. Higher doses of minoxidil will increase the chances of side effects. For full details of minoxidil side effects please click here.