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New Insight Into Causes of Male Pattern Baldness


Professor Cotsarelis The Belgravia Centre

Breakthrough: Professor George Cotsarelis has spent years studying follicles in order to find the causes of hair loss

Male Pattern Baldness, or Androgenic Alopecia, affects somewhere in the region of 80% of men by the time they reach 70. Scientists have known for many years that Androgenic Alopecia that the chemical dihydrotestosterone has a direct role in causing hair follicles in the scalp of older men to shrink and eventually stop producing visible hair altogether. However, ground breaking research has revealed a certain protein that has a significant influence on reducing the growth of hair in men, and as such causes male hair loss.

U.S. Scientists reveal a new culprit

In the United States, scientists studying both humans and mice have discovered that a particular protein – called prostaglandin D synthase – was found in higher concentrations in bald patches on the scalp, but not in areas that where hairs were still growing. Research project leader Professor George Cotsarelis said, “Essentially we showed that prostaglandin protein was elevated in the bald scalp of men and that it inhibited hair growth. So we identified a target for treating Male Pattern Baldness. The next step would be to screen for compounds that affect this receptor and to also find out whether blocking that receptor would reverse balding or just prevent balding – a question that would take a while to figure out.”

The potential for new treatment

Hair growth is reduced when prostaglandin D synthase molecules bond to receptors on the surface of hair follicle cells. This causes the hair follicles to produce hair shafts more slowly than usual, and over time, they reduce in size, causing hair coverage to thin noticeably. Now that this pathway has been identified by scientists, a number of drugs are being developed that will target it; preventing hair loss and even promoting the regrowth of hair. However, as Professor Cotsarelis says, it is unknown if blocking this pathway will cure baldness as well as preventing it.

Treatment options now

There are already a number of treatments already available that have been clinically proven to prevent baldness – namely Propecia and Minoxidil – both of which are part of the treatment regimens that the experts at The Belgravia Centre produce Belgravia Productsfor our patients, along with a number of hair growth boosters and clinical after-care services. Belgravia’s hair loss treatment courses will help prevent hair loss or regrow hair in the great majority of cases, as the men and women in our hair loss success stories found out for themselves.

If you would like to arrange a consultation at our London clinic please contact us on 0800 077 6666 or by messaging the centre. Alternatively you can complete our online diagnostic form for our national mail-order service.

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