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A global trial that will look into a new application method for one of the most commonly-used hair loss drugs is now recruiting volunteers to take part.

The study been announced by Swiss pharmaceutical company Polichem, and the randomised, double-blind Phase 3 trial is hoping to enlist an impressive 450 volunteers who will be involved over a six-month period.

Finasteride 1mg Aindeem tabletsTopical finasteride

The trial is certainly of interest to the medical community as Polichem has announced that it will be using a topical version of the drug finasteride, one of just two MHRA and FDA approved drugs for the treatment of Male Pattern Hair Loss. Normally, this drug is taken orally.

At more than 60 sites across Belgium, Germany, Spain, Russia and Hungary, the Polichem trial will explore the clinical efficacy and safety of what has been named P-3074. The company further describes this as a cutaneous spray solution.

Participants must all be aged between 18 and 40, and they must be displaying moderate to advanced hair thinning that registers as type III vertex, IV or V on the Norwood Hamilton scale. They must also be willing to have a tiny tattoo on their scalp, so that testers can easily return to the same area on their scalp during the study.

In an earlier Polichem trial involving 60 men with androgenetic alopecia, Essex-based testers employed by the company announced that Ultraviolet light would be used during treatment, apparently to cause a reaction that would make the drug more effective. There is no specific mention of UV light being used this time around.

The finasteride used in the trial will be a 0.25 per cent solution, and a percentage of the volunteers will be given the more traditional oral version of finasteride in usual 1mg doses so that results can be compared.

There are a long list of reasons why people may be excluded from this particular trial, including abnormal scalp findings, hair transplant surgery and a history of infertility. Use of any of a large number of drugs would render an applicant unsuitable, too, including finasteride and also minoxidil – the other MHRA and FDA approved Male Hair Loss Treatment. The study is slated for completion by the end of 2017.

Tailored treatment plan

At Belgravia, men with hereditary hair loss are first assessed then diagnosed by a specialist who then provides them with a comprehensive list of options tailored to their medical requirements, level and pattern of shedding. Typically they will recommend a combination approach which includes both oral finasteride 1mg and minoxidil to be applied directly to the scalp and specifically chosen from a number of high strength minoxidil products available from Belgravia’s in-clinic pharmacies.

Alongside these key medications, a tailored treatment plan can include a number of other elements to help maximise regrowth. Hair Growth Boosters such as Hair Vitalics, a food supplement for healthy hair growth which contains a proprietary blend of essential vitamins, minerals, amino acids and botanicals is formulated to help nourish the scalp. The HairMax LaserComb, meanwhile, uses low level laser light energy to penetrate soft tissue on the scalp and can encourage hair growth. A choice of these boosters can often be included free of charge to Belgravia clients when a full annual hair loss treatment course is purchased.

Additionally, the support that men receive throughout their treatment course from trained professionals is frequently mentioned as being an enormous relief, as well as motivational.

While the Polichem trial is certainly interesting, for men worried about a thinning crown or receding hairline, there are already proven hair loss solutions that can help to both stop hair falling out and also encourage new growth. The best place to start is with a professional consultation.


The Belgravia Centre Hair Loss ClinicThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

male pattern hair loss the belgravia centre 09 02 2017A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Gradual improvement to the overall hair density can be seen in this happy patient’s check-up photos.

Find out what this client had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

male pattern hair loss the belgravia centre 09 02 2017A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

This happy patient has seen improvement in the areas affected by his hereditary hair loss condition.

Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Minoxidil Foam Hair Loss TreatmentName: Sarah

Question: Hi. I’ve been using minoxidil 5% foam for 3 weeks. What I want to know is – it says you can experience more hair loss to begin with and that it’s a positive sign. I am not experiencing more than normal amount of shedding. Does this mean that this won’t work for me? Thank you, Sarah.

Answer: Hi, Sarah. As you are not a Belgravia client we would recommend you speak to your minoxidil provider for personalised hair loss advice. However, what we can tell you on a general note is that, firstly, although it is common, not everyone experiences extra shedding after starting minoxidil. Also – for those who do – it can take longer than three weeks for this to start happening.

It does not necessarily mean that your minoxidil foam will not work as, generally, it will take at least three-to-six months, depending on how advanced the hair thinning when treatment was started, in order to tell whether or not it is having the desired effect. If after that time you still see no changes, we recommend getting a second opinion as it may be that you are better suited to a different formulation.

At Belgravia we often recommend combining a recommended high strength minoxidil formulations alongside appropriate hair growth boosters to women experiencing hairloss. Relevant products can be tailored into a custom hair loss treatment course designed to address the individual’s specific needs, for a highly-targeted and personalised approach. If you find that you are not seeing the improvements you were hoping for from your current treatment at the three-to-four month mark, one of our hair loss specialists would be happy to give you their opinion. Simply book in for a free consultation at one of our Central London hair loss clinics or, if you are based elsewhere in the UK or abroad, just complete the online consultation form on our website.


circ - Belgravia Centre Hair Loss Clinic Laser TherapyThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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For most men, dealing with hair loss is no laughing matter – which is probably why footballer Cristiano Ronaldo knew he’d put his foot in it when he recently teased a former colleague.

In the tunnel before a match between Real Madrid and Espanyol, Ronaldo approached his old Real teammate Diego Lopez and according to The Sun said, “Wow, Diego, you’ve had like 3,600 hairs put in!

Ronaldo and LopezJibe taken in good spirits

Goalkeeper Lopez appeared to take it all in good spirits, but Ronaldo turned away from the TV cameras lurking in the tunnel with his head in his hands. His “swallow me up” moment was obviously inspired by reports that Lopez has had a hair transplant to help him deal with the receding hairline that had been caused by the genetic condition Male Pattern Baldness.

According to Dr Ezequiel Panno, a surgical hair restoration specialist based in Marbella, former Real Madrid goalie Diego Lopez is one of many footballers to have had this type of procedure. Others include Wayne Rooney, who is believed to have had at least two, and Blackburn Rovers’ Anthony Stokes.

Some of the longstanding stigma attached to hair transplants seems to be steadily disappearing – and not just in football circles. The trend for hairloss surgery has boomed in the past few years, helped by high profile footballers and celebrities including James Nesbitt and Calum Best speaking openly about their operations (both have had two and three hair transplants each, respectively). The dropping cost of having surgery abroad has also helped the popularity of surgical hair restoration, though this is widely acknowledged to carry a number of risks.

For those in the public eye, “coming clean” and owning up to having had this type of work done can be unavoidable, especially with the rise in social media meaning anyone can be a paparazzo and share incriminating shots worldwide, instantly.

Signs of a transplant are evident for several weeks after an operation, so footballers often undergo hair restoration operations during the summer close season when they typically have over a month off. This allows them plenty of time away from the cameras to recouperate. For those men with regular jobs where taking a month off isn’t quite so easy, a male hair loss treatment course can provide a more private, convenient option instead. This carries with it the advantage that, through gradual results and no other outward signs, no one need know about it.

Based around clinically-proven, MHRA and FDA approved drugs – finasteride 1mg and minoxidil – bespoke courses have helped men around the world to stop shedding and regrow their hair.

Treatment before transplant

What is interesting is that many hair transplant surgeons actively encourage patients to undergo hair loss treatment for six months before they have a hair transplant. This gives the surgeons more hair to work with by the time the operation comes around, and in some cases men are so pleased with their regrowth that they cancel the operation.

In order for a transplant to be deemed a success in the long-term, it is essential that a pharmaceutical hair loss treatment course is followed on an ongoing basis. This is because the hairs surrounding the newly-implanted grafts will be just as susceptible to the problems caused by a potent testosterone by-product named DHT, as before. What happens in men who are genetically predisposed to male pattern baldness is that this hormone causes follicles to gradually shrink and wither, causing thinning hair and even eventual baldness. Treatment can be used both to inhibit the production of DHT – which has no other use after puberty – and to promote hair growth.

According to recent reports, Ronaldo’s teammate Gareth Bale could be the next player to visit a hair transplant surgery. The Welshman has been displaying a pronounced thinning crown, which may have been caused by the tight man-bun he has so often worn. If that is the case, a secondary condition known as Traction Alopecia may need to be factored into the equation.

It could be that Ronaldo learned to put his foot in it in terms of people’s hair when working under Jose Mourinho, the legendary football manager who held the reins at Real Madrid from 2010-2013. Mourinho has something of an ongoing feud with Manchester City manager Pep Guardiola, and in 2014 claimed that the then-Bayern Munich boss didn’t enjoy football because he was bald. “If you enjoy what you’re doing, you don’t lose your hair,” he said.


Circ - Hair Loss Treatments Regrow hair Belgravia Centre Clinic LondonThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

traction alopecia follicular degeneration syndrome the belgravia centre 27 03 2017A new entry has just been added to Belgravia’s women’s hair loss treatment Success Stories gallery.

Janet, pictured, has two separate conditions – Traction Alopeciaand Follicular Degeneration Syndrome which are being treated simultaneously, thanks to a personalised treatment plan, based around a high strength minoxidil product available from Belgravia, as devised by her dedicated hair loss specialist.

Find out what Janet had to say about her regrowth results so far and see them close up, or find out more about treating Traction Alopeciaor Follicular Degeneration Syndrome by clicking the buttons below…

 

VIEW SUCCESS STORY

TRACTION ALOPECIA TREATMENT

FOLLICULAR DEGENERATION SYNDROME TREATMENT

 


The Belgravia Centre Hair Loss ClinicThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

hypothyroidism - thyroid disorder - hair lossName: Marilyn

Question: I have recently been diagnosed with a HYPOTHYROID. I am getting very thin hair on my right side (front). Is there something I can do to slow down or stop this hair loss.

Answer: Hi, Marilyn. In order to answer your question thoroughly we would ideally need to know how long you have been noticing this hair loss for and whether it is affecting anywhere else on your scalp.

The reason for this is that hypothyroidism and hair loss are often linked, especially when the condition has only recently been uncovered or is undiagnosed.

When you have an underlying illness the body can temporarily divert its attention away from what it considers ‘non-critical functions’ in order to help fight this. This can affect the hair growth cycle and cause hair thinning from all over the scalp, although this may not become noticeable until around three months after the shedding begins. When this occurs, it is due to a hair loss condition called Telogen Effluvium which tends to last for a maximum of six months. If the illness continues without being treated, or if the prescription medication used to treat the condition – in this case diabetes – causes hair loss as a side effect, then the shedding may continue for at least six months and becomes chronic.

Telogen Effluvium can be treated, although it will often clear up of its own accord, and Chronic Telogen Effluvium treatment can also often help to accelerate regrowth in more severe cases, providing the underlying illness is also being properly managed. However, if you have a genetic predisposition towards hereditary hair loss – androgenic alopecia, better known as Female Pattern Hair Loss – this condition can be triggered by either form of Telogen Effluvium.

Although this condition only causes thinning hair along the top of the scalp and the hairline, whereas the previously mentioned hairloss conditions are temporary and can affect the whole scalp, this is permanent and progressive. As you have a very specific area of your scalp that is being affected and which could apply to both of these types of hair loss, we would recommend having a personal consultation – either in person or online – so that you can receive a professional diagnosis. There are effective hair loss treatments for women, as well as various additional hair growth boosters, that can be tailored into a personalised course to stabilise current hair fall and promote regrowth.


Circle - The Belgravia Centre Hair Loss Clinic - Clinical Therapy TreatmentThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

male pattern hair loss the belgravia centre 09 02 2017A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr Charitra is thrilled with his regrowth to date saying he is “already seeing the benefits.”

Find out what this client had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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A five-year study designed to assess the safety of a possible future treatment for hair loss has concluded, with the company behind the trial saying it had met all “primary endpoints.”

The trial was organised by Vancouver-based RepliCel, a pioneering stem cell research company whose expertise in the field has led it to believe that the technology may be ripe for exploitation as a solution to Male Pattern Baldness.

Pharmaceutical Company Replicel Is Looking to Use Stem Cell Technology to Advance Genetic Hair Loss TreatmentsTrichoScience trail

As with many clinical trials, information is often relatively limited, but it now appears that this particular trial is the same one that Belgravia has covered on this hairloss blog before and pertains to work undertaken at the Scientific Research for Skin and Venereal Diseases in Tbilisi, Georgia. That trial was initiated by a company named TrichoScience Innovations, which was acquired by RepliCel in 2011.

RepliCel seems to be involved in several studies into the use of stem cells as a possible treatment for genetic hair loss, including one in Japan. There, it has teamed up with a company named Shiseido, and created headlines last year when it was rumoured that its treatment could be released by 2018.

But what exactly is RepliCel doing? The answer is not a thousand miles removed from what hair transplant surgeons do – namely trying to physically insert new hairs into areas around the top of the head or hairline where there are currently none, or where thinning hair or a receding hairline is apparent.

Existing, non-surgical Male Pattern Hair Loss Treatment courses take a somewhat different approach. Utilising two clinically-proven products – finasteride 1mg and minoxidil – androgenetic alopecia is tackled at a biological level. Used together, they can form a powerful two-pronged attack.

Hair Loss Treatment ResearchSafety first

RepliCel’s goal, however, wasn’t to test the efficacy of its treatment this time around; its aim was to check for side effects, tolerance and overall safety. The results, says the company, were a success, and prompted RepliCel President and CEO R. Lee Buckler to tell the media: “As we march toward commercialisation of this product based on this first-in-human data, our aim is to revolutionize the way we prevent, treat, and even reverse hair loss.

The product in question is known as RCH-01, and was tested on a total of 19 patients (20 being the original goal). As to what RCH-01 actually is, the company describes it thus: “RCH-01 is an autologous cell therapy utilising dermal sheath cup (DSC) cells isolated from the hair follicle to treat androgenetic alopecia. To manufacture RCH-01, dermal sheath cup cells are isolated from a small punch biopsy taken from the back of a subject’s scalp. These cells are replicated in a GMP compliant cell production facility and the cells are then injected into balding areas on the same subject’s scalp.”

Naturally, the medical team involved in the study took note of any hair growth that arose out of the trial, although it states that this was not statistically significant. In fact, it could be said that the findings are perhaps underwhelming even for a small scale trial, with the seven “top-tier” respondents to treatment recording a greater than 10 per cent increase in hair density at six months. At 24 months, the average hair density increase for these same patients was 8.3 per cent over baseline. The largest increase over 24 months in a single patient was 21 per cent.

Effective treatments now

RepliCel says it will now use the findings to hone potential future treatments. It says the findings will inform “basic decisions about further development, provide provocative insights into the product’s potential, and – perhaps most importantly – provide useful feedback which we can use to drive decisions about process and product development, ongoing research, and future clinical trial parameters.”

It could be years before any such products are developed and acknowledged as both safe and effective in large scale trials. In the meantime, there are already effective and clinically-proven, MHRA and FDA approved hair loss solutions. The hair loss treatments used by the specialists at Belgravia, to significant regrowth effect in the great majority of cases, include the oral one-a-day DHT inhibitor, finasteride 1mg often alongside recommended formulations of a topical solution known as high strength minoxidil. Each of these primary medications can be used alone, however we find that combination courses tend to produce the best results for our male hairloss clients.

Belgravia’s approach of tailoring the optimum selection of medications and hair growth boosters for each individual client’s pattern and level of shedding, and monitoring their progress throughout in order to make any necessary tweaks as they go along, has produced copious success stories so if you are concerned about thinning hair, rest assured there is help available now.


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


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HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Can You Apply Scalp Oil if You Use Minoxidil?Name: Nilesh

Question: I am using argan oil hair loss treatment but it is not working. My hair is thinner than before. I apply every night and every day but still my hair loss. What can I do?

Answer: Hi, Nilesh. Argan oil is one of a number of natural products that people believe can treat hair loss but, sadly, this is untrue.

Although argan oil has moisturising properties and is high in vitamin C, which is known to help nourish the skin, these are cosmetic effects. They may help to improve the condition of the existing hair but they do not deal with a hair loss condition.

There are no authorised natural hairloss treatments and only two pharmaceutical medications that have been clinically-proven to treat male pattern baldness – the most common cause of thinning hair in men.  These hair loss treatments are designed to work on a biological level – something that cannot be achieved by cosmetic hair care products such as hair oils. These pharmaceutical treatments are called finasteride 1mg and minoxidil.

Finasteride 1mg is a once-a-day tablet designed to block the enzyme DHT that men with male pattern hair loss have an inbuilt sensitivity towards and which is the cause of this gradual hair thinning. Belgravia specialists often recommend combined courses where this tablet is taken and a topical solution of high strength minoxidil is applied directly to the scalp, where needed, in order to promote hair growth.

When following such a treatment regime hair oils can still be used on the scalp if you wish, however it is important that you apply the minoxidil first and allow it to sink in to the scalp for as long as possible – at least 20 minutes – before applying the oil.


The Belgravia CentreThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


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29 Mar

Success Story Alert! New Male Hair Loss Treatment Entry

A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery. Gradual improvement to the overall hair density can be seen in this happy patient’s check-up photos. Find out what this client had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking […]

Read full article »
29 Mar

Success Story Alert! New Male Hair Loss Treatment Entry

A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery. This happy patient has seen improvement in the areas affected by his hereditary hair loss condition. Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons […]

Read full article »
29 Mar

‘Does Lack of Extra Hair Thinning Mean Minoxidil Is Not Working?’

Name: Sarah Question: Hi. I’ve been using minoxidil 5% foam for 3 weeks. What I want to know is – it says you can experience more hair loss to begin with and that it’s a positive sign. I am not experiencing more than normal amount of shedding. Does this mean that this won’t work for me? Thank […]

Read full article »