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Maria Fowler and Kelvin BateyIn what could well be a UK first, celebrity couple Maria Fowler and her champion BMX-racing boyfriend Kelvin Batey have taken steps to deal with their hair loss issues by having his ‘n’ her transplants.

The pair signed up for the procedure at one of the UK’s many hair restoration clinics – where operations often cost in excess of £5,000 – and it appears that they underwent hair transplant surgery at roughly the same time. Both Batey and the former TOWIE star went in with the same goal: each wanted to restore their hairline, though the underlying causes of their thinning edges are quite different.

Genetics, hairstyles and hair loss

Men who find that they have a receding hairline can almost always blame the genetic condition Male Pattern Baldness, an extremely common hair loss condition that can strike any time following puberty, though it becomes more likely with each passing decade. Not every man is susceptible to male pattern hair loss, however: it is only those with an inherited genetic predisposition towards it who will be affected.

While genetic hair loss can also affect women – and female pattern hair loss, like its male equivalent, is incredibly common, though far less talked about – it would appear that Ms Fowler’s frontal shedding has a different cause.

What seems likely is that she had lost some hair to Traction Alopecia, an entirely avoidable condition that is a result of choices people make about how to wear their hair. Tight hairstyles that place strain on the scalp, such as braids and high ponytails, are common causes of Traction Alopecia as they place undue stress on the hair follicles. When offending styles are worn frequently they can cause damaged follicles and ensuing hair loss.

Equally problematic and a common a cause of Traction Alopecia today are hair extensions – something Ms Fowler is no stranger to wearing and was even pictured raving about on social media just four days before her transplant. The hairline and temple areas tend to be worst affected, though hair loss and breakage around the sites were the styles or extensions are fixed may also occur, as they bear the brunt of the tension and extra weight from these hairstyles.

An educated guess, therefore, would suggest that overuse of hair extensions and her favoured high ponytail hairstyle may have led to Ms Fowler developing Traction Alopecia. It is unclear what prompted her to take the unusual and drastic step of signing up for surgery to fix her damaged hairline though, especially as there is an effective, non-surgical solution in the form of Traction Alopecia treatment. For Belgravia clients this involves wearing the hair naturally and loosely in order to allow the follicles to recover, whilst using topical applications of recommended formulations of high strength minoxidil to the affected areas, alongside additional hair growth boosters, until sufficient regrowth is achieved.

Pictures of the couple attending a party a short time after their transplants show how they both have what look like a multitude of tiny red dots at the front of their heads. These are from where individual hairs harvested from the back of their heads – where the hair is more abundant – have been painstakingly implanted into their hairlines. Some people have described the procedure as extremely painful, and it is famously slow to perform, with many hours of surgery needed, though the timeframe – like the cost – depends on the number of grafts involved in the operation.

Aftercare and alternatives to hair restoration surgery

Batey will hopefully have been warned by his surgeon that while his new grafts will no longer be susceptible to Male Pattern Baldness, existing hairs surrounding them still will be. If so, he will likely have been told that following an on-going pharmaceutical male pattern hair loss treatment course is advisable. This can reduce the likelihood of thinning around the hairline and also the top of the head, and can even encourage regrowth of new hairs.

Male hair loss treatment is widely used by those interested in stabilising hair fall, encouraging regrowth and preventing baldness, and is the preferred option for many men who would rather not go down the transplant route. There are two clinically-proven, MHRA and FDA-approved medications which are often used as part of a non-surgical treatment programme: finasteride 1mg and minoxidil.

The first, finasteride 1mg is a one-a-day tablet that inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is DHT which causes the gradual hair thinning associated with male hair loss. It binds to the sensitive follicles around the top of the head and hairline, slowly destroying them. As they become smaller and weaker, this displays outwardly as thinning hair or receding, with increased hair fall. If left unchecked, it can lead to eventual baldness.

Thinning Hair Before and After Male Hair Loss Treatment at The Belgravia Centre - Success

Click to view Belgravia Male Hair Loss Treatment Success Stories (Results May Vary and Are Not Guaranteed)

By minimising the amount of DHT in the system, hair growth should continue unhindered. However, finasteride’s effect on frontal hair loss is unproven. This is one of the key reasons why, at Belgravia, bespoke treatment courses often include recommended formulations of the vasodilator high strength minoxidil from those available at the clinic’s in-house pharmacies.

These solutions are applied directly to the scalp where needed, and help to promote localised blood flow, encouraging healthy hair growth. Belgravia’s hair loss specialists have found this approach, especially as part of a combination treatment course, to be especially effective in cases of stubborn areas, such as a receding hairline or thinning crown.

This two-pronged attack can be further enhanced by the use of additional hair growth boosters. These include follicle-stimulating low level laser therapy (LLLT) via a handheld, home-use device, and nutritional support via highly-targeted Hair Vitalics for Men hair growth supplements.

The results of a systematic review of which hair loss treatments work was published in May 2017, with minoxidil, finasteride and LLLT being confirmed as the most effective. So, bearing this in mind – as well as the fact that top surgeons recommend waiting until at least 30 years of age before considering a transplant – for anyone concerned about signs of hair loss or a receding hairline, having a consultation with a specialist who can provide a diagnosis, advice and treatment recommendations could be a wise first port of call.


The Belgravia CentreThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 13 10 17A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr A, pictured, is thrilled with his results to date saying he’s “delighted to see that the treatment has made a noticeable difference in the short time-span”.

Find out what else he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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HairlossANSWERS - Click to Submit Your Query to Our Hair Loss Experts

Name: Tanya

Question: Hi, I’m in my early 40s and have covered my hair for religious reasons for 15 years. Whilst I’ve always naturally had fairly thin blonde hair, since covering I have been experiencing extreme thinness all over – as well as excessively greasy. Would any treatment still work even though my hair would remain covered even after regrowth, or is there not much point in me trying?
Many thanks.

Religious head covering hair loss womenAnswer: Hi, Tanya. You head covering is unlikely to have any effect either on your hair loss nor diminish the effects of any treatment.

The first thing to do would be to establish why you are experiencing thinning hair. Given the length of time you have been noticing hair fall and your age we would suspect this was due to female pattern hair loss, a common, permanent genetic condition that is inherited and affects the top of the scalp and hairline. However, a consultation would be required in order to provide an accurate diagnosis following assessment by one of our specialists.

On the question of whether or not there is any point in trying hair loss treatment, this is entirely up to you. What we can tell you is that a personalised treatment regime can help to maintain current hair density and improve hair growth as much as possible. Women’s hair loss treatment is based around topical applications of a solution called high strength minoxidil. Although this can cause temporary hair shedding in some people when it is first used, this is generally a good sign that old thin hairs are being shed to make way for stronger regrowth.

In addition to using direct applications of minoxidil, hair growth boosters can be employed to further maximise results, scalp and hair health. These products range from the FDA-cleared LaserComb LLLT home-use device, to nutritional support via Belgravia’s exclusive Hair Vitalics for Women hair growth supplements. These contain a potent blend of high quality, key vitamins, minerals, amino acids and botancial extracts identified for their hair-friendly properties, including zinc, biotin, selenium and soy isoflavones – the latter of which have been shown to reduce serum DHT. DHT being the testosterone by-product which causes female pattern hair loss in women with an inherited sensitivity to it.

Belgravia clients following custom hair loss treatment courses generally tend to see improvements within the first three months of starting their course – though this can vary from person to person and depends on the extent of the shedding when starting treatment. If you are curious as to the levels of hair regrowth you may experience from using a personalised treatment course, you could start with a 6 to 12 month regime to try it out. We would certainly, however, recommend a consultation as your first port of call in order to ascertain a confirmed diagnosis as to your hair loss condition so that suitable treatment recommendations can be made accordingly.

With regards oiliness, we recommend washing your hair daily or every other day with a shampoo specifically designed for oily hair. If you wish to use a conditioner, apply it only to the ends of your hair as applying it to the roots will only encourage oiliness.


Circle - The Belgravia Centre Hair Loss Clinic - Clinical Therapy TreatmentThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert female pattern hair loss the belgravia centre 12 10 2017A new entry has just been added to Belgravia’s Female Pattern Hair Loss Treatment Success Stories gallery.

Ms L, pictured, is very happy with her regrowth and tells us she “would encourage anyone who has doubts to keep up the treatment”.

Find out what else she had to say and see her regrowth results close up, or find out more about treating hereditary hair loss in women by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


The Belgravia Centre Hair Loss ClinicThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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NBA star LeBron James’s hair loss has been the butt of pundits’ jokes and intense media scrutiny for some time – and the legendary player seems in no rush to let the talk of his thinning edges die down.

LeBron James Receding Hairline 2013

LeBron James’ 2013 Sports Ilustrated Cover Highlights His Receding Hairline

For many years, basketball icon James – one of the world’s highest paid athletes – kept quiet about his receding hairline, which became the subject of great debate when he arrived at a match several years ago sporting much thicker-than-normal-looking hair. His changing appearance was even documented in video games NBA2K13, 14 and 15, with the first release depicting James with a full head of hair which became noticeably thinner for the following year’s version. For NBA2K15, his hairline was fully restored.

Temporary hair loss solution?

But it looks like whatever solution the baller settled on when he took action a few years ago wasn’t permanent, as recent footage shows that his hair now seems to be on the thin side again.

James finally admitted his hairloss issues during a post-game press conference this summer when he was paying tribute to his hero Michael Jordan and said, “I didn’t go bald like Mike, but I’m getting there.”

Now, the popular 32-year-old has taken to social media to joke about his thinning hair, which he is losing to the genetic condition Male Pattern Baldness. “Is it not fair that he can grow his hair like that,” James says in an Instagram video shot in the gym where he is joined onscreen by his thick-haired Cleveland Cavaliers teammate, Dwyane Wade. “Why can’t I just Velcro this off?” he says, tugging at his own luxurious beard. “And put it on top of here,” he adds, slapping a hand down on his head. Continues below…

When James’ receding hairline was transformed in 2014, appearing much fuller than it had previously, several theories emerged. One was that the player had had a hair transplant – something he would likely have been a good candidate for as he had plenty of donor hair at the back of his head. Another option was that he had signed up for a male hair loss treatment course. A third possibility was that he had actually used a powerful dye named Bigen, which is marketed towards African American men. This third option, however, was dismissed by his hairdresser in 2015 when he said: “There’s no dye. Everyone thinks he’s dyeing his hair using Bigen or Black Ice. It’s all his hair.”

Treatment to help regrow a receding hairline

Male Pattern hair loss treatment is a popular option around the world because, when used consistently, it can often halt shedding and even result in newly-grown hair, preventing baldness in the long-term. If the return of James’ hair was indeed attributable to this method, it would appear that he may have stopped using it, or has not been using a bespoke course tailored to his precise needs. As there is no cure for genetic male pattern hair loss, it is important to continue treatment on an on-going basis in order to continually manage this permanent condition.

Non-surgical men’s hair loss treatment is extremely popular, and Belgravia clients frequently write to say how much they appreciate and are encouraged by the support they get from the Centre’s hair loss experts as part of their course.

There are two clinically-proven, MHRA and FDA-approved medications – finasteride 1mg and minoxidil – which are frequently used as part of these treatment programmes, alongside additional hair growth booster products.

The first, finasteride 1mg, is a daily tablet that inhibits the conversion of testosterone into DHT, which is what causes the gradual hair thinning associated with male hair loss. It binds to the follicles around the top of the scalp and hairline, and, in men who have a genetic sensitivity to it, it gradually makes these follicles smaller and weaker. This shows outwardly as thinning hair and can lead to eventual baldness if left unchecked as once the follicles are irreparably damaged, hair loss follows.

By minimising the amount of DHT in the system, hair growth should continue unhindered. However, finasteride’s effect on frontal hair loss is unproven. This is one of the key reasons why, at Belgravia, treatment courses often include recommended formulations of high strength minoxidil from the range at the clinic’s in-house pharmacies.

The beauty of male hair loss treatment courses is that they can be quietly taken without anyone knowing; hair usually regrows gradually, and when both successful and used early enough, they may help to restore hair before the thinning even becomes noticeable to anyone else. Even for those who start treatment once signs of hair loss are highly visible, as long as the follicles are still active, it is likely that results may be pleasing. While James may not be among the sportsmen to have signed up for long-term treatment, there are certainly plenty of others who have and – from the looks of his scalp in images – it looks like there’s still time for him to follow their lead.


Circ - Male Pattern Baldness hair loss treatment Belgravia Centre clinic LondonThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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Losing your hair to the autoimmune disorder Alopecia Areata is often difficult – especially when you’re a child and every school day is another reminder of your hair loss and how different you look.

For several years now, Mattel, the makers of Barbie, have been making a “bald and beautiful” version of their popular doll named Ella – and as one heart-warming Facebook video shared by America’s National Areata Foundation (NAAF) showed recently, it continues to put a smile on people’s faces.

Martina’s delight

The video, posted to NAAF’s Facebook page, features a young girl with Alopecia Areata named Martina, from Italy. Her mother sent in the video, which shows Martina carefully unboxing her Ella and – after a few moments of slight bewilderment – her delight at finding that the doll’s wig comes off.

Martina’s hair loss is a classic example of Alopecia Areata, with patches dotted around her scalp, and like many people with the condition, she has cut her hair very short to take the emphasis away from the bald spots. Her bald Ella doll is like a miniature version of herself. Continues below…

The doll was originally produced after a social media campaign that generated more than 100,000 likes on Facebook, and today the dolls are given out at children’s hospitals in the US, as well as by the NAAF – one of only three organisations through whom the unique toys are distributed. Each doll comes with a set of accessories, such as a headband and a wig.

The brilliant thing about Ella is that she helps to normalise Alopecia Areata for children, and in a very simple way helps them to see that they are not alone during what is always a very trying time. Worry, in fact, often forms a significant part of a child’s Alopecia Areata journey, as doctors are unable to say whether it will clear itself up, spread or return.

Also, whilst Alopecia Areata treatment for those aged 16 and over is available, and success rates can be extremely encouraging, options for children are more limited. For parents of a child with the condition it can be an extremely stressful time.

Stress is actually one of several suspected triggers for this quite widespread autoimmune disorder (around three per cent of people will be affected in their lifetime); shock and sudden extreme stress, as well as physical trauma are among the factors that are often identified as the likely reason why the body is attacking itself, leading to hair falling out.

Book stars girl with Alopecia Areata

Anything that parents can use to help their little ones get through Alopecia Areata is to be welcomed, and a new book from award-winning author J.M. Forster is no exception. Her new book, Bad Hair Days, was launched to mark the start of Alopecia Awareness Month in September 2017.

It is based around a girl called Mallow who has patchy hairloss from Alopecia Areata, and starts wearing a wig to try and conceal it. The author told her local news website Gloucestershire Live: “I’m excited to celebrate the release of Bad Hair Days in Alopecia Awareness month. Hair loss can be an embarrassing and distressing condition for young people, but if we were more accepting of people’s differences, it doesn’t need to be that way.”


The Belgravia CentreThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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A leading Washington DC cosmetic dermatologist has revealed that when men come to him to freshen up their appearance, their number one concern is nearly always hair loss.

Talking to the refinery29.com website, Dr Terrence Keaney says that around 60 to 70 per cent of his clients are male (it is a sector he specifically markets to) and a “decent amount” of these are politicians. When they come in to see him, he says, they tend to tell him who they don’t want to look like as opposed to who they would like to resemble, and their concerns, he says, usually begin with their hair.

Clock ageing timeHair loss can age a man

Most men categorically do not want to lose their hair – and perhaps with good reason: researchers in Germany found that men who feel youthful are more successful than those who don’t. Another study found that visible signs of hair loss adds up to eight years to a man’s perceived age. Greying hair adds up to seven years, while being heavily unshaven can add up to three.

Male pattern baldness is an hereditary hair loss condition, which can be inherited from either side of the family though recent research suggests this is most likely to be passed on through the father’s side of the family. Because of this, an emotional link often exists between hairloss and ageing, because a man remembers his own father losing his hair. In turn, this can lead to the feeling that a man is effectively turning into his own dad – someone they have witnessed growing old before their very eyes.

“Men think about ageing differently and have different concerns,” says Dr Keaney. “There are three major areas they tend to focus on when they look in the mirror. Hair loss and hair thinning is, by far, the biggest concern. It’s the number one thing that ages a man.”

He adds: “Men care about their appearance ­– just look at luxury fashion or skincare sales – but have been largely ignored in the dermatology field, so they think that treatments aren’t for them.”

While this statement may be true when it comes to the likes of facial fillers like Botox, it is less so when it comes to hair loss treatment, a field in which men are well-served in relation to effective treatments for the genetic condition Male Pattern Baldness.

Regrowing hair and preventing baldness

Most men associate genetic hairloss with the ageing process – even though thinning can begin at any time post-puberty if a man has a predisposed sensitivity to a testosterone by-product named DHT (dihydrotestosterone). DHT latches on to sensitive follicles situated around the top of the scalp and hairline, causing them to produce weaker, thinner hair over time, ultimately leading to hair loss. Because of this ingrained fear of hair thinning, male pattern baldness is often tackled as soon as evidence of it is spotted, often through following a male hair loss treatment course.

Belgravia’s hair loss specialists are often asked if it is possible to start a treatment course before they start losing their hair in order to prevent hair loss from affecting them. The answer to this is, no – the simple reason being, you may not have the genetic makeup for male pattern baldness! This type of hereditary hair loss can even skip generations if it does run in the family, so following an unnecessary treatment regime ‘just in case’ is not advised. Should any signs of thinning or a receding hairline start to become noticeable, however, at that point a professional diagnosis should be sought and – where appropriate – personalised treatment recommendations will be made at that point.

There are currently two clinically-proven, MHRA-licensed and FDA-approved hair loss treatments for male pattern baldness; one comes in tablet form (finasteride 1mg) and inhibits DHT production, the other, which complements this, is a topical vasodilator named minoxidil. Applied directly to the scalp where it is needed, this solution opens up potassium channels in the scalp and encourages regrowth.

At Belgravia, clients tend to use combination courses comprising recommended formulations of high strength minoxidil, as well as taking the once-a-day DHT-blocker, finasteride 1mg and using additional hair growth booster products. This three-pronged approach is followed by many men who want to regrow lost hair to successfully manage this permanent hair loss condition, as well as helping them to prevent baldness through on-going use.

One advantage of this type of non-surgical route is that it can deal with hair loss discreetly. Though looking through before and after photographs showing men before and then months after starting their hair loss treatment regimes may clearly show quite a spectacular difference, the change happens gradually. The new hair growth and improvements in density may even make clients feel more confident and appear younger. As Belgravia Male Hair Loss Treatment client, Gaetano – pictured, says: “6 months into the treatment and I can see incredible results. Very very happy with it. My friends say I look younger!”


Hair Vitalics for Men food supplement for hair growth CIRCThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 11 10 17A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr R, pictured, is thrilled with his treatment results to date saying it “has been a great change to my personal life”.

Find out what else he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

VIEW SUCCESS STORY

TreatmenT information 

 


Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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People with psoriasis – including scalp psoriasis – may soon be getting help from the unlikeliest of sources.

Psoriasis is a chronic, long-term condition whereby the skin’s cell turnover is quicker than normal. This causes dry, red, flaky patches of skin covered with silvery-white scales and can be extremely itchy.

According to new research from Emory University in Atlanta, a compound derived from fire ant venom may reduce skin thickening and inflammation. Successful tests already performed on mice have proved the theory.
Scalp Psoriasis example
Symptoms can often be eased through management using various forms of treatment and/or therapy, including when it affects the scalp. Depending on the severity of the condition, treatment would likely be administered both in a clinical and at-home setting, and could include nutrition and lifestyle changes in addition to medications and therapies. According to healthline.com, more than 50 per cent of people with psoriasis will develop scalp psoriasis.

Autoimmune disorder

Like Alopecia Areata, a disorder which leads to sudden hair loss – from scalp-only patchy bald spots to complete baldness of the head and body, psoriasis is an autoimmune disorder. Both issues are known to have stress-related triggers. Topical steroids are most commonly used to treat psoriasis, but their side effects include easy bruising and a thinning of the skin.

The researchers in Atlanta were already interested in the properties of fire ant venom, the main toxic components of which are called solenopsins, which had proven to be an inhibitor in blood vessel growth and that has potential as an anticancer agent. They had also observed that solenopsins chemically resemble ceramides – lipid-like molecules that are essential for maintaining the barrier function of the skin, and are found in many skin-care products.

Dermatology professor Jack Arbiser, MD, PhD, lead author of the study (DOI: 10.1038/s41598-017-10580-y), says that ceramides can have a downside, however, pointing out that they can sometimes be converted by cells into S1P (sphingosine-1-phosphate), which is actually an inflammatory molecule.

fire antsAccording to the Amery University website, Arbiser and his colleagues devised two solenopsin analogs that look like ceramides, but which can’t be degraded into S1P. They then tested these in a mouse model of psoriasis, applying the compounds in a one percent skin cream for 28 days.

The results were remarkable: mice treated with solenopsin analogs displayed skin thickness decreases of around 30 per cent when compared to controls. They also had almost half the amount of immune cells infiltrating the skin than the control group. When applied to immune cells in culture, the compounds decreased the cells’ production of the inflammatory signal IL-22 and increased production of anti-inflammatory IL-12.

Body’s immune response

IL is an abbreviation of interleukin, a group of cytokines in the blood that play a large part in the body’s immune response. Importantly, these proteins are frequently mentioned in relation to Alopecia Areata, and doctors in Nice have suggested that low doses of the IL-2 protein could be beneficial to people with severe forms of the condition.

Meanwhile, the use of the interleukin IL-13 investigated during an American trial into a potential treatment for Alopecia Areata, doctors stated that: “Data shows that IL-13 is significantly unregulated in both atopic dermatitis and Alopecia Areata lesions compared to nonlesional skin. It is very important to associate the clinical responses with suppression of this cytokine and related molecules as well as other pathway cytokines in skin tissues.”

Says Emery’s Jack Arbiser: “We believe that solenopsin analogs are contributing to full restoration of the barrier function in the skin. Emollients can soothe the skin in psoriasis, but they are not sufficient for restoration of the barrier.”

The scientists also looked at how patterns of gene activity were changed in the skins of the mice after treatment. Solenopsin analogue application turned down genes that are turned up by current treatments such as steroids and ultraviolet light.

“This may be compensatory and a mechanism of resistance to anti-psoriasis therapy, and it suggests that the solenopsin compounds could be used in combination with existing approaches,” Arbiser says.


Circ - Belgravia Centre Hair Growth supplements boosters lasercombThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


Related Stories


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Belgravia Centre Hair Loss Treatment Before and After Results - New Success Story

alert male pattern hair loss the belgravia centre 11 10 2017A new entry has just been added to Belgravia’s Male Hair Loss Treatment Success Stories gallery.

Mr B, pictured, was initially sceptical but after his first check-up, he’s very happy with the results.

Find out what he had to say and see his regrowth results close up, or find out more about treating Male Pattern Baldness by clicking the buttons below…

(Results may vary and are not guaranteed)

 

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Belgravia Centre Hair Loss Clinic Hair Loss Specialist Free ConsultationThe Belgravia Centre

The Belgravia Centre is the leader in hair loss treatment in the UK, with two clinics based in Central London. If you are worried about hair loss you can arrange a free consultation with a hair loss expert or complete our Online Consultation Form from anywhere in the UK or the rest of the world. View our Hair Loss Success Stories, which are the largest collection of such success stories in the world and demonstrate the levels of success that so many of Belgravia’s patients achieve. You can also phone 020 7730 6666 any time for our hair loss helpline or to arrange a free consultation.


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